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K. Lepik



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    P1.17 - Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies (ID 703)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
    • Presentations: 1
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      P1.17-019a - Pathological Discrepancies in the Diagnosis of Thymic Malignancies: The Tallinn-Lyon Experience (ID 8990)

      09:30 - 09:30  |  Author(s): K. Lepik

      • Abstract

      Background:
      Thymic malignancies are rare thoracic tumors for which pathological diagnosis is complex due to multiple subtypes and variations in interobserver reproducibility. In this study, we aimed at analysing the consistency between initial diagnosis in the largest thoracic oncology center in Estonia, and one of the expert center for thymic pathology in France.

      Method:
      Hospital electronic database and pathology databases from the Tallinn North Estonia Medical Centre were searched for thymic and mediastinal tumors from 2010 to 2017. Pathology specimens were referred to the Pathology Department of the Lyon University hospital.

      Result:
      Figure 1 55 tissue specimens from 49 patients were included (Table 1). The quality of pathology reports was assessed, with tumor size, diagnosis, and invasion mentioned in ≥80% of cases, while resection status and staging were assessed in 52% and 31% of cases, respectively. The initial diagnosis was consistent with that of the review in 60% of cases. Minor discrepancies - regarding thymoma subtype - were observed in 20% of cases. Three patients had normal thymus according to the reference centre, whereas thymoma B1 or B2 had been diagnosed locally, including one patient with severe myasthenia gravis. Three patients had implications for treatment due to the major differences in pathohistological diagnoses.



      Conclusion:
      Implementing structured pathology reports may help to decrease discrepancies in the diagnosis of thymic malignancies. The development of expert networks is an opportunity in this setting.