Author of

• 20162

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  P1.13 - Radiology/Staging/Screening (ID 699)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Radiology/Staging/Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24613

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    P1.13-011b - Nodal Status Based on the Anatomical Location or the Number of Lymph Nodes Metastasis (ID 9012)

    09:30 - 09:30  |  Author(s): M. Suzuki
    • Abstract

    Background:
    The 8th edition of the TNM staging system for lung cancer has been published. In the new staging system, the N component remains the same as in the previous version. However, the number of involved nodal stations has been previously shown to be correlated with patient outcomes. In the present study, we retrospectively investigated the correlations between the anatomical location versus the total number of metastatic lymph nodes and the outcomes of patients with non-small cell lung cancer.
    
    Method:
    We retrospectively collected 237 samples (16.1%) from patients with pN1 and N2 primary lung cancer who underwent complete resection between 2004 and 2013. In those samples, we divided N1 samples into N1ss (single station N1) and N1ms (multiple station N1). We also divided samples into hilar N1 (#11, #10; N1h) and peripheral N1 (#14, ＃13, and #12; N1p) subgroups. pN2 lymph nodes were divided into “single station N2 with skip metastasis” (N2ss1), “single station N2 with N1 metastasis” (N2ss2), and N2ms. The clinicopathological factors and outcomes for each group were statistically analyzed.
    
    Result:
    In this study, per patient, a mean of 17.9 lymph nodes were dissected and the mean number of lymph node metastases was 3.9. The pN1 and pN2 groups consisted of 74 and 163 cases, and their 5-year survival rates were 74.7% and 54.8%, respectively (p = 0.021). The 5-year survival rates of the N1p and N1h groups were 74.7% and 63.6%, respectively. Although the N1h group showed a tendency towards poorer outcomes, no statistically significant difference between the groups was observed (p = 0.114). The 5-year survival rates of the N2ss1 and N2ss2 groups were 65.4% and 62.4%, respectively, and the N2ms group had poorer outcomes (45.0％, p = 0.010). In our cohort of patients with N1 and N2 lymph node metastasis, the number of metastatic lymph nodes was not correlated with patient outcomes.
    
    Conclusion:
    In the cases of pN1, patients with N1h had poorer outcomes than those with N1p. In the cases of pN2, patients with N2ms had poorer outcomes than those with other subsets of pN2. From a prognostic point of view, classification based on the anatomical location of metastatic lymph nodes may be important. Further accumulation and examination of cases will be necessary to confirm our findings.