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K. Gocho



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    P1.07 - Immunology and Immunotherapy (ID 693)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Immunology and Immunotherapy
    • Presentations: 1
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      P1.07-044b - Pretreatment Neutrophil/Lymphocyte Ratio and the Efficacy of Nivolumab Treatment in Non–Small-Cell Lung Cancer (ID 9375)

      09:30 - 09:30  |  Author(s): K. Gocho

      • Abstract
      • Slides

      Background:
      The blood neutrophil/lymphocyte ratio (NLR) before ipilimumab administration is a useful predictive biomarker in the treatment of malignant melanoma. However, few studies have evaluated whether NLR can predict and overall survival in non–small-cell lung cancer (NSCLC).

      Method:
      We studied 38 patients with previously treated advanced NSCLC who had received nivolumab therapy between January 2016 and May 2017 at our hospital. Patients were divided into two groups (pretreatment NLR <5 or ≥5), and patient characteristics, treatment effect, adverse events, and immunohistochemical expression of programmed death ligand 1 (PD-L1) were evaluated in both groups.

      Result:
      Of the 38 patients, 12 had an NLR ≥5 and 26 had an NLR <5. Regarding patient characteristics, median PD-L1 expression on immunohistochemistry was significantly higher in the NLR <5 group than in the NLR ≥5 group (38.2% vs 1.7%, respectively; p = 0.049). The objective response rate was 39.1% vs 12.5%, respectively (p = 0.17), and the disease control rate was 95.7% vs 25%, respectively (p <0.001). The disease control rate significantly differed between groups, as did progression-free survival (median progression-free survival: 132 days in the NLR <5 group vs 49 days in the NLR ≥5 group; p = 0.009).

      Conclusion:
      Among patients treated with nivolumab for NSCLC, disease control rate and progression-free survival were better for patients in the NLR <5 group than for those in the NLR ≥5 group. The association between pretreatment NLR and immunohistochemical PD-L1 expression warrants further study.

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