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H.S. Hershkovich
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P3.07 - Immunology and Immunotherapy (ID 723)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Immunology and Immunotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.07-013c - Computational Simulations for Investigating Electric Field Distributions When Delivering Tumor Treating Fields (TTFields) to the Lungs (ID 8776)
09:30 - 09:30 | Author(s): H.S. Hershkovich
- Abstract
Background:
Tumor Treating Fields (TTFields) are low intensity, alternating electric fields in the intermediate frequency range. TTFields disrupt mitosis, and are FDA approved for the treatment of glioblastoma. A study testing the efficacy of TTFields in combination with chemotherapy for the treatment of mesothelioma [NCT02397928] is ongoing , and a pivotal study testing the efficacy of TTFields in treating NSCLC was recently launched [ NCT02973789]. TTFields are delivered through two pairs of transducer arrays placed on the patient's skin. Preclinical research shows that treatment efficacy increases with the intensity of the field. Therefore, optimizing treatment requires a deep understanding of how TTFields distribute within the body. . Here we present a computational simulations-based study investigating the field distribution in male and female realistic computational phantoms when arrays are placed on the thorax
Method:
Simulations were performed using the Sim4Life software package realistic computational phantoms of a male, female and obese male (ZMT, Zurich, Switzerland). Arrays with a geometry similar to that used to deliver TTFields to the thorax with the NovoTTF-100L were placed on the chests of the models, and delivery of TTFields was applied by imposing boundary conditions simulating a 4 ampere peak to peak current at 150 kHz. The field intensities within the lungs of the models were then evaluated.
Result:
The highest field intensities within the lungs were obtained when the arrays were axially-aligned with the parenchyma as much as anatomically possible. Under these conditions, field intensities throughout the lungs exceeded the therapeutic threshold of 1 V/cm in all models. Array layouts in pairs delivered electric fields from the anterolateral to the posterior-contralateral aspect of the patient and from the antero-contralateral to the posterolateral aspect of the patient, respectively, resulted in high intensity relatively uniform field intensities through the lungs. These types of layouts could be used on male subjects. However, due to body contours, these cross-body layouts may not adhere well to females, potentially hampering the efficient delivery of TTFields. For the female phantom, a layout in which one pair of arrays is placed on the lateral and contralateral aspects , and the second set of arrays placed on the anterior and posterior aspects may be the preferred layout.
Conclusion:
This study provides insights into how transducer array layouts influence TTFields distribution in the lungs. These results should be accounted for when treating lung cancer with TTFields.
