Virtual Library
Start Your Search
A. Luca
Author of
-
+
P3.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 722)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
-
+
P3.06-009a - Lung Cancer in the Elderly - Histology, Localization and Gender Distribution in North Romania (ID 10237)
09:30 - 09:30 | Author(s): A. Luca
- Abstract
Background:
Lung cancer remains one of the most challenging conditions due to its poor prognosis. Extensive data regarding changes in cancer histology, sex-specific incidence and tumor localization are available for developed countries in Europe and the US. However, for countries where there is no unified and comprehensive cancer registry, these data are scarce. Additionally, data from elderly individuals, that represent a significant proportion of all lung cancer patients, are insufficient. The aim of the study was to provide an analysis of lung tumor characteristics in elderly patients from North-East Romania.
Method:
We retrospectively analyzed all lung cancer cases admitted to the Regional Institute of Oncology (a territorial unit responsible for the diagnosis and treatment of cancer patients in Moldova) from 2012 to 2017. We then selected the elderly patients (aged over 75 at the time of diagnosis) and collected several types of data, such as sex, age, histology, stage, EGFR status and localization (right versus left lung).
Result:
We identified 201 patients over 75 years old at the time of diagnosis. Average age was 77.1±2.1, with a median of 77 and a maximum of 90 years. The male to female ratio was 3.27:1. Regarding histology, most cancers were adenocarcinomas (32.8%), followed by squamous cell carcinomas (30.8%) and atypical/undetermined histology (25.4% - carcinoid tumor, adenosquamous tumor or large-cell carcinoma). Females were more likely to have adenocarcinoma, while males were more likely to have squamous cell carcinoma. Most patients were diagnosed in stage IV (53.7%), with more males being diagnosed in earlier stages when compared to females. We found that a very large proportion of the adenocarcinoma patients was not tested for the EGFR mutation (25.4% of the stage III or IV adenocarcinomas). Of those tested for EGFR, 33% had a mutation present, all female. Right lung tumors were more frequent than left lung tumors (62.2% vs 37.8%) in both sexes.
Conclusion:
Elderly patients represent an important segment of the individuals affected by lung cancer. Most likely due to their age, they are diagnosed in advanced or metastatic stages and additional Immunohistochemical staining and/or EGFR testing are sometimes omitted. Our data for Romanian patients is mainly in accordance with available literature, although we found an unusually high percent of tumors with atypical histology in elderly patients.
