Author of

• 20195

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  P3.16 - Surgery (ID 732)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24273

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    P3.16-050 - Stromal PDGFR-β Expression Influences Postoperative Survival of NSCLC Patients Receiving Preoperative Chemo- or Chemo-Radiotherapy (ID 8871)

    09:30 - 09:30  |  Author(s): N. Takakura
    • Abstract
    • Slides

    Background:
    Platelet-Derived growth factor beta (PDGFR-β) is a functional regulator of mesenchymal cells. It is reported that PDGFR-β is expressed by cancer associated fibroblasts, and PDGFR signaling supports cancer cells. Stromal expression of PDGFR-β is reported to be associated with poor prognosis in prostate, breast, pancreas, and gastric cancers. However, the significance of stromal PDGFR-β expression in non-small cell lung cancer (NSCLC) in patients undergoing preoperative chemo- or chemoradio-therapy had not been undetermined.
    
    Method:
    Seventy-two patients with NSCLC undergoing preoperative chemo- or chemoradio-therapy between 1996 and 2006 were assessed for expression of stromal PDGFR-β by immunohistochemistry using resected specimens. After cancer cells and stromal tissues were identified by HE staining, stromal PDGFR-β expression was defined as positive when it was observed in >5% of the stromal area. Relationships between stromal PDGFR-β expression and disease-free survival (DFS) and disease-specific survival (DSS) were analyzed.
    
    Result:
    The mean age of the 72 patients was 59.7 years. Sixty-one (85%) were male and 11 (15%) female. Forty patients (56%) underwent preoperative chemoradiotherapy and 32 patients (44%) underwent preoperative chemothearapy. Indications for preoperative chemotherapy were N2 disease in 51 (71%), T3 or T4 disease in 20 (28%), and other reasons in the remaining patient (1%). Regimens for preoperative chemotherapy were cisplatin (CDDP)-based in 34 patients (47%) and carboplatin (CBDCA)-based in 37 (52%). Type of resection were pneumonectomy in 7 (10%), bilobectomy in 6 (8%), lobectomy in 57 (79%), and sublobar resection in 2 (3%) patients. Complete resection were achieved in 59 patients (82%). The pathologic stage (7[th] ed.) was IA in 11 (15%), IB in 12 (17%), IIA in 6 (8%), IIB in14 (19%), IIIA in 19 (27%), IIIB in 5 (7%), and IV in 5 (7%) patients. The histological type were adenocarcinoma in 32 (44%), squamous cell carcinoma in 35 (49%), and others in 5 (7%) patients. On immunohitological examination, stromal cells expressed PDGFR-β in 47 cases (65%). Five-year DFS and DSS in the stromal PDGFR-β-positive group was significantly worse than in the negative group (29.1%-vs-64.6%, p=0.01 and 40.2%-vs-66.1%, p=0.02, respectively).
    
    Conclusion:
    Stromal PDGFR-β expression is negatively associated with DFS and DSS in patients with NSCLC undergoing preoperative chemo- or chemoradio-therapy.
    
    

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