Author of

• 20195

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  P3.16 - Surgery (ID 732)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24265

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    P3.16-042 - Intraoperative Hyper-Thermotherapy with Distilled Water for StageIV Lung Cancer (ID 9218)

    09:30 - 09:30  |  Author(s): T. Yamada
    • Abstract
    • Slides

    Background:
    Non-small cell lung cancer (NSCLC) with dissemination are classified as Stage IV lung cancer and usually considered inoperable. However, dissemination detected primarily during thoracotomy has been reported to show better prognosis compared with dissemination diagnosed clinically. Here, we present a case series of surgically treated stage IV lung cancer treated with intraoperative hyper-thermotherapy with distilled water.
    
    Method:
    Clinical records of 912 consecutive NSCLC patients who underwent surgery intended for complete resection between 2006 and 2016 were retrospectively reviewed. 5 M1a cases and 1 M1b (posterior mediastinum) case were treated with intraoperative hyper-thermotherapy with distilled water. Thoracic cavity was filled with distilled water heated to 43 degrees Celsius, following segmentectomy / lobectomy and lymphadenectomy.
    
    Result:
    All cases were pathologically T2 adenocarcinomas. 3 had pN2 status, and 3 had pN0 status. 3 had EGFR mutation, with adjuvant EGFR-TKI therapy. Recurrence was confirmed in 2 cases; 1) pT2aN2M1a, tumor size 3.5 cm with no EGFR mutation, 2) pT2aN0M1b tumor size 2.5 cm with no EGFR mutation. The median observation period was 14 months (8-31) with 2year recurrence free survival rate of 53.3% and 2year overall survival rate of 66.6%. 2 cases showed a significant decrease of serum CEA post operatively. No pleural effusion was confirmed post operatively among the surviving cases. Figure 1
    
    
    
    Conclusion:
    Stage IV lung cancer cases with dissemination detected during thoracotomy have tolerable survival rates when combining intraoperative hyper-thermotherapy with distilled water post segmentectomy / lobectomy and lymphadenectomy. Multidisciplinary treatment, including surgery, for Stage IV lung cancer requires further consideration as it has potential for better prognosis.
    
    

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