Author of

• 20195

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  P3.16 - Surgery (ID 732)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24256

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    P3.16-033 - Significance of Spread through Air Spaces in Resected Pathological Stage I Lung Adenocarcinoma (ID 9182)

    09:30 - 09:30  |  Author(s): Y. Yamada
    • Abstract

    Background:
    Spread through air spaces (STAS) is a novel invasive pattern of lung cancer, which spreads within air spaces beyond the edge of the main tumor, but not necessarily accompanying stromal invasion. In the current study, we investigated the significance of STAS in patients with pathological stage I adenocarcinoma.
    
    Method:
    STAS was assessed in a total of 276 patients with resected pathological stage I adenocarcinoma. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20x objective and a 10x ocular lens. We evaluated the association between STAS and the clinicopathological characteristics and postoperative survivals.
    
    Result:
    Among 276 patients, 123 (44.6%), 48 (17.4%) and 105 (38.0%) were classified as having no, low and high STAS, respectively. Fisher’s exact test demonstrated that positivity for STAS was significantly associated with a larger radiological tumor diameter (P=0.008), a higher consolidation/tumor ratio (P<0.001), a higher maximum standard uptake value (P<0.001), a pathologically larger tumor size (P=0.004), the presence of pleural invasion (P=0.027) and a histologically invasive type (P<0.001), while STAS was not significantly associated with epidermal growth factor receptor mutations or programmed death ligand-1 expression (P=0.129 and P=0.872, respectively). Patients with the STAS had significantly shorter recurrence-free and overall survivals than those without (P<0.001 and P=0.002, respectively). According to a multivariate analysis, positivity for STAS remained an independent prognostic parameter for both the recurrence-free and overall survivals.
    
    Conclusion:
    STAS was associated with clincopathologically invasive features and was predictive of a worse survival. Figure 1