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E. Nasser
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P3.14 - Radiotherapy (ID 730)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.14-003 - Patterns of Follow-Up Care After Curative Radiotherapy for Stage I-III Non-Small Cell Lung Cancer (ID 9707)
09:30 - 09:30 | Author(s): E. Nasser
- Abstract
Background:
Evidence regarding optimal follow-up (FU) strategies for patients after curative radiotherapy for NSCLC is limited, resulting in variable FU practice. The aim of this study was to describe the patterns of FU care for patients undergoing curative radiotherapy +/- chemotherapy.
Method:
A retrospective study was conducted of patients with Stage I-III NSCLC, undergoing a course of curative radiotherapy (a minimum dose of 50Gy), between 1/1/2007-31/12/2011 at three institutions. Data was collected from oncology records, including patient demographics, tumour characteristics, treatment and follow-up. At each FU, the reason for FU (routine or symptomatic), specialist seen and imaging performed were recorded, until an event (recurrence or new primary) was diagnosed. The censor date was 31/12/2016. Analysis of FU included univariate chi-square tests for categorical variables, t-tests for continuous variables, multivariate logistic regression analyses, and Kaplan Meier survival curves.
Result:
Two-hundred-and-eighty-three patients (183 males, 100 females) were identified with a median age of 72(36-91) years. Eighty-four (29.7%) were Stage I, 47 (16.6%) were Stage II, and 152 (53.7%) were Stage III. Pathology was large cell in 91 patients (32.2%), squamous cell in 100 (35.3%), adenocarcinoma in 68 (24.0%), and NSCLC NOS in 24 (8.5%). One-hundred-and-sixty-five (56.5%) patients received radiotherapy alone and the remaining 123(43.5%) received chemoradiotherapy. The average frequency of FU visits per year was 5.12, median number of FU visits to first event was 6, and median time to first event was 11 months. 73.7% of FU were routine, while only 16.2% were symptomatic. 1641 imaging tests were performed, equating to an average of 5.8 scans per patient, with only 98 resulting in a diagnosis of an event. Overall, recurrences were diagnosed in 175 patients of whom 85 were symptomatic and 90 diagnosed on routine imaging. New primaries were diagnosed in 23 patients, 15 with symptoms and 8 on routine imaging. Subsequent treatment was curative in 25 (14.3%) patients with recurrent disease and 18 (85.7%) with new primaries. Univariate and multivariate analysis determined that the method of diagnosis of an event (symptomatic vs routine) had no statistically significant impact on the intent of further treatment (curative treatment 13.8% v 7.7%, p=0.089) or on overall survival (2y OS 49.5% vs 51.6%, p=0.772).
Conclusion:
Following curative radiotherapy, patients undergo frequent FU with regular imaging. Despite this only a minority of patients who develop recurrence are suitable for curative treatment. The use of routine imaging did not impact on further curative treatment or improve overall survival.
