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D. Groshar
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P3.13 - Radiology/Staging/Screening (ID 729)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiology/Staging/Screening
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.13-030 - Metabolic Parameters of FDG PET at Early Evaluation of NSCLC Differ with Histological Subtypes (ID 10173)
09:30 - 09:30 | Author(s): D. Groshar
- Abstract
Background:
Fluorodeoxyglucose Positron emission tomography (FDG PET) is a main tool in diagnosis and staging in patients with non small cell lung cancer (NSCLC). Metabolic parameters as standardized uptake value (SUV) and total lesion glycolysis (TLG) were reported to have independent prognostic and predictive value in different stages of disease and were shown to correlate with tumor activity and tumor burden. However, little is known regarding the correlation of these parameters with histologic subtypes of NSCLC. In this study we aimed to explore associations of FDG PET metabolic parameters in patients diagnosed with NSCLC and histologic subtypes of NSCLC.
Method:
We retrospectively evaluated 87 consecutive patients who underwent FDG PET scans in the workup of pulmonary nodules highly suspicious for malignancy. At total of 62 of them were found to have NSCLC; 44 with adenocarcinoma (ADC) and 18 with squamous cell carcinoma (SQCC). Measurements of hounsfield units (HU), region of interest (ROI), SUVmax, SUVmean, volume of interest (VOI) and TLG were obtained. Follow up for final staging at diagnosis and overall survival (OS) were obtained from electronic medical records. Statistical analysis was made with T-test and Mann-whitney u test.
Result:
In patients with SQCC, the mean ±standard deviation (SD) SUVmax and TLG (±SD) were found to be significantly higher than in patients with ADC (Table 1). Differences in OS showed a trend favoring SqCC but no significance was found (complete results from 16 more patients are pending). Figure 1
Conclusion:
FDG PET Metabolic characteristics such as SUVmax and TLG significantly differ between histological subtypes in NSCLC. This report joins others on the utility of functional imaging studies in NSCLC in assessing not just disease burden but also prognosis and function. Further analyses of the PET parameters prognostic impact according to histology subtype is ongoing and would be presented at the meeting.
