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P.A. Taveggia



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    P3.13 - Radiology/Staging/Screening (ID 729)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Radiology/Staging/Screening
    • Presentations: 1
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      P3.13-006 - Correlation between CT Morphology at the Diagnosis and EGFR Status in Patients with Adenocarcinoma of the Lung (ID 8192)

      09:30 - 09:30  |  Author(s): P.A. Taveggia

      • Abstract
      • Slides

      Background:
      Aim of the study was to correlate epidermal growth factor (EGFR) mutation status with computed chest tomography (CT) image patterns at the diagnosis in patients with lung adenocarcinoma.

      Method:
      Patients diagnosed between January 1, 2015 and March 3, 2017 with available CT and EGFR mutation status were analyzed. The maximal diameter of the nodules, shape (mix, solid) , presence of an air bronchogram and calcification, specula, incision, round shape, central necrosis, pleural connection, UH pre e post were evaluated.

      Result:
      87 patients (52 males, median age 66 years, range 43-87) were enrolled. 9, 36 and 42 patients had stage II, III and IV, respectively. EGFR mutations were found in 22 patients (25.3%; 1 exon 18, , 15 exon 19 deletions and 6 exon 21 mutations) and were more frequently among females (45.2% versus 18.6% males, p=0.020) and never smokers (77.8% vs 11.8% smokers, p<0.001). The median maximal diameter of the nodules was smaller in mutated patients (30.5, range 15-74 mm) than in wild-type patients (45.0, range 13-110 mm; p=0.010). Tumors with exon 21 mutations were smaller than wild type tumors (p=0.014). Mutations were statistically more frequent in solid pattern (30.6% vs 0 mixt, p=0.010). A higher number of mutations, not statistically significant, were also found in presence of tumors with regular margins (31.9% vs 17.5% spiculati, p=0.14), no incisions (30% vs 5.9% with incision, p=0.059), no central necrosis or calcification (26.3% vs 14.3% with central necrosis or calcification, p=0.67), no calcification (26.3% vs 14.3% with calcification, p=0.67). Median tumor density was 35 UH in wild type vs 40.0 UH in mutated tumors (p=0.29) and 70 UH in wild type vs 80 UH in mutated tumors (p=0.17), before and after contrast, respectively.

      Conclusion:
      Adenocarcinomas with EGFR mutations were associated with smaller tumors and with solid pattern.

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