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M. Kim
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P3.13 - Radiology/Staging/Screening (ID 729)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiology/Staging/Screening
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.13-002 - Reduced Dose Perfusion CT of Lung Cancer using a 16-cm Coverage Scanner: Effects of Respiratory Motion Correction on Perfusion Assessment (ID 7464)
09:30 - 09:30 | Author(s): M. Kim
- Abstract
Background:
Perfusion CT parameters have showed promising results for evaluation of tumor response and follow-up. However, clinical implications in patients with lung cancer have been relatively limited due to the fact that perfusion CT is performed while the patient is breathing and high radiation dose. Therefore, the purpose of this study was to evaluate the effects of respiratory motion correction on perfusion assessment of lung cancer in a reduced dose perfusion CT using a 16-cm coverage scanner.
Method:
Eighty four patients with primary lung cancer who underwent a reduced dose perfusion CT (80 kVp, 80 mA) were enrolled in this study. Each perfusion CT study included 25 repeated dynamic CT scans obtained using the volume perfusion software and was reconstructed with hybrid iterative reconstruction at a strength level of 50%. Two observers measured blood flow (BF), blood volume (BV), and permeability of the entire tumor with and without the use of non-rigid registration algorithm. Single-measure intraclass correlation coefficients (ICC) were calculated and interobserver reproducibility for parameters obtained with two different manners were assessed through Bland-Altman analyses.
Result:
CTDIvol obtained with each of the dynamic perfusion CT in this study was 36.16 mGy and the estimated mean effective dose ranged from 2.02 mSv to 4.0 mSv. Using non-rigid registration, all ICC values for BF, BV, and permeability were increased (0.982~0.994 to 0.988~0.997) compared with those obtained before application of non-rigid registration. All ICC values of lower lung tumor (0.991~0.998) or tumor ≤ 3 cm (0.989~0.998) were higher than those of upper lung tumor (0.925~0.984) or tumor > 3 cm (0.975~0.996). Using non-rigid registration, all 95% limits of interobserver reproducibility were narrowed compared with those obtained before application of non-rigid registration, regardless of tumor location or tumor size, except those of BV for tumors located in upper lung and tumors > 3 cm.
Conclusion:
Perfusion assessment of lung cancer using a reduced dose perfusion CT scan is clinically feasible and application of respiratory motion correction using non-rigid registration can reduce measurement errors.
