Author of

• 20187

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  P3.08 - Locally Advanced Nsclc (ID 724)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Locally Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 24124

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    P3.08-002 - Lymphovascular Invasion Is Not a Postoperative Prognostic Factor for Large-Sized Lung Cancer (ID 9643)

    09:30 - 09:30  |  Author(s): T. Shigenobu
    • Abstract

    Background:
    Numerous studies about small-sized lung cancer have been published recently. On the other hand, few studies have considered large-sized tumors. In this study we analyzed the prognostic factors for tumors that measured 5 cm or more.
    
    Method:
    Of the 547 patients who underwent resection of the lung due to primary lung cancer in our institution between 2002 and 2011, 90 had tumors that measured 5 cm or more. Among these 90 patients, 43 were adenocarcinomas, 32 were squamous cell carcinomas, 68 were male, and 14/26/1 cases were pathological N1/2/3, respectively. The average age was 70.1±8.9 years, and the average tumor diameter was 6.7±1.9 cm. Age at operation, gender, tumor location, operative method, tumor size, nodal status, lymphatic permeation, vascular invasion, pleural invasion (pl), preoperative pulmonary function status, serum carcinoembryonic antigen level, smoking status, and Charlson comorbidity index were analyzed using a Cox proportional hazards model to identify the postoperative prognostic factors.
    
    Result:
    In a univariate analysis, tumor size of 7 cm or more (p = 0.03), pathological N status of N2 or more (N0 vs. N2/3: p = 0.03), pl3 (pl0 vs. pl3: p=0.02), and < 80 (p=0.04) were found to be associated with a poor postoperative overall survival (OS). Lymphatic permeation (p = 0.66), and vascular invasion (p=0.10) were not significantly associated with OS. A multivariate analysis was performed using the 4 factors that were associated with a poor OS in the univariate analysis. As a result, tumor size of 7 cm or more (p < 0.01), pathological N status of N2 or more (N0 vs. N2/3: p < 0.01), and pl3 (pl0 vs. pl3: p=0.01) were independently associated with a poor OS.
    
    Conclusion:
    For large-sized lung cancer, tumor size, nodal status and pleural invasion were related to OS, whereas lymphovascular invasion was not.