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G. Xu



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    P3.05 - Early Stage NSCLC (ID 721)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Early Stage NSCLC
    • Presentations: 1
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      P3.05-003 - Serum Thioredoxin Reductase 1 as a Diagnostic Biomarker for Non-Small Cell Lung Cancer (ID 8235)

      09:30 - 09:30  |  Author(s): G. Xu

      • Abstract
      • Slides

      Background:
      Non-invasive diagnostic biomarkers for patients with suspicious non-small cell lung cancer (NSCLC) may provide needed guidance on invasive diagnostic and therapeutic decisions. Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme, and plays an important part in tumor growth, progression, metastasis, and chemotherapy resistance. The goal of this study is to test the feasibility of developing plasma TrxR1 as a novel diagnostic biomarker for NSCLC.

      Method:
      The plasma TrxR1 activity was determined spectrophotometrically by monitoring the NADPH-dependent production of 2-nitro-5-thiobenzoate at 412nm and at 37℃. A random forests method was adopted to identify and measure the important diagnostic variables for NSCLC. A nomogram that allowed more accurate prediction of probability for NSCLC was developed.

      Result:
      In this study, the plasma levels of TrxR1 were measured in 102 treatment-naïve NSCLC patients and 11 individuals with benign tumor-like pulmonary diseases. The random forest analysis identified that TrxR1, PET SUVmax, smoking and drinking history were potentially significant variables for NSCLC diagnosis and differentiation. After cross validation, the nomogram for the cohort was accurate and discriminating, with an area under the receiver operating characteristic (ROC) curve of 0.70. Figure 1



      Conclusion:
      Our data suggest that plasma TrxR1 activity is a useful non-invasive diagnostic marker for NSCLC. We developed a user-friendly nomogram that uses information commonly available to the clinician to easily and accurately calculate the likelihood of NSCLC.

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