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P. Ranganathan
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P3.02 - Biology/Pathology (ID 620)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.02-081 - Nutritional Status Assessment in Treatment Naïve Patients with Lung Cancer (ID 8900)
09:30 - 09:30 | Author(s): P. Ranganathan
- Abstract
Background:
Malnutrition is multifactorial and frequently co-exists in patients with cancer. Cancer-related anorexia, cachexia and side effects of anticancer therapy can lead to inadequate nutrient intake and subsequent malnutrition. Lung cancer is the leading cause of cancer and cancer-related mortality globally and most patients present in an advanced stage. Nutritional status has a direct effect on the performance status, tolerance to treatment and outcomes.
Method:
We performed a cross-sectional, observational study in the outpatient department of a tertiary referral cancer hospital involving nutritional assessment of treatment-naïve patients with lung cancer. Patients who consented were assessed by two nutritionists using the patient reported subjective global assessment(SGA) and mini nutritional assessment (MNA) tools. Data collected included history, physical and anthropometric measurements. Assuming a prevalence of 33%, the required sample size was calculated to be 400.
Result:
400 patients were recruited between August 2015 and January 2016. The mean age of patients was 58 years and 72% were male. The mean body weight was 57 kilograms and the mean body mass index (BMI) was 21.9 kg/m2. The mean hemoglobin was 12.4 gm% and the mean albumin was 3.9 gm%. 50% of patients were smokers, and 34.7% of the smokers also chewed tobacco. 95% of the smokers were male; 21% consumed alcohol. 64.5% of patients had lost weight, and 60% had anorexia. Most patients presented in advanced stages, with 60.75% in stage IV and 24% in stage III. Nutritional status assessed by the Subjective Global Assessment (SGA) score showed that 24.5% were well nourished (SGA “A”), 64.5% were at risk of malnutrition (SGA “B”) and 11% were malnourished (SGA “C”). Using the Mini Nutritional Assessment (MNA) score, 80.7% of patients were found to be malnourished or at risk of malnutrition with 19.3% patients considered to have normal nutritional status. No significant correlation was found between age, ECOG status, smoking, disease stage or weight loss and the nutritional status scores. There was moderate agreement between the SGA and MNA scores with a kappa coefficient of 0.44.
Conclusion:
Malnutrition is widely prevalent in patients with lung cancer. Formal nutritional assessment using universally acceptable tools like the SGA or MNA should be a part of the work up of the patient along with staging and diagnosis. Early identification can guide nutritional intervention in order to improve the performance status and enable patients to receive and tolerate cancer directed therapy.
