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  P3.02 - Biology/Pathology (ID 620)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23968

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    P3.02-020 - Comparison of Diagnostic Ability for EGFR Mutation of the Specimen Groups: Histology – Cytology – Plasma (ID 7495)

    09:30 - 09:30  |  Author(s): T.D. Thanh
    • Abstract
    • Slides

    Background:
    EGFR mutations in NSCLC therapy play a very important role. Currently, many types of specimens are used to perform EGFR mutations. At Pham Ngoc Thach Hospital with RealTime-PCR Technique on cobas [@] z 480 machine has been done on a variety of clinical specimens.
    
    Method:
    ~- Research with cross sectional descriptive statistics.~ ~- Period from November 2016 to May 2017: 6 months.~ ~- Diagnose EGFR mutations in 3 groups: histology, cytology, plasma.~ ~- Control check with next-generation gene sequencing.~
    
    Result:
    - Total number research: 56 cases with 26 EGFR mutation (+) with next generation sequencing. - Histology specimens: EGFR (+): 44.64%; Sensitivity: 96.15%, Specificity: 96.67%; Number of cases to be resumed: 0 shifts; Not quantifiable. - Cytology specimens: EGFR (+): 42.86%; Sensitivity: 92.31%; Specificity: 96.67%; Number of cases to be resumed: 2 cases for the second time; Not quantifiable. - Plasma specimen: EGFR (+): 33.93%; Sensitivity: 73.31%; Specificity: 96.55%; Number of cases to be resumed: 12 cases for the second time, 7 cases for the third time; Average mean quantity: 15.66 ± 7.05 ng / μl. → Statement: * Use a variety of specimens to diagnose EGFR mutations. * Sensitivity and detection rates of histological and cytological specimens were higher than plasma samples. * The specificity of these three groups is comparable. * It is not possible to determine when to get the best blood sample for the plasma diagnosis of EGFR mutation. * Plasma samples have the advantage of being semi-quantifiable. So consider predictive factor evaluates the treatment.
    
    Conclusion:
    * Histology and cytology specimens are more sensitive and detectable than in diagnosis of EGFR mutation. Therefore, this is an important factor in the diagnosis. * Semi quantitative in plasma specimen to monitor treatment response & some cases to diagnose when no re-biopsy is available.
    
    

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