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A. Nuño
Author of
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P3.01 - Advanced NSCLC (ID 621)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.01-065 - Advanced NSCLC with EGFR Mutations in Elderly Patients. Single-Centre Experience (ID 10195)
09:30 - 09:30 | Author(s): A. Nuño
- Abstract
Background:
Along the past 10 years determination of EGFR mutational status has becoming part of the standard clinical practice for NSCLC patients. It is also acknowledged that median age of NSCLC patients is progresively increasing and nowadays a significant percentage are elderly when diagnosed. The aim of this paper is to analize the characteristics of NSCLC-EGFR-mutated patients that were 75 years or older at diagnosis and assess their survival.
Method:
EGFR-mutated patients with advanced NSCLC treated betweeen June/2010 and June/2016 in our Department were analyzed. The subgroup of those >75 years have been reviewed for assessment.
Result:
Out of the 73 patients with EGFR mutation, 22 (30.1%) were 75 years or older. Median age was 80.5 y (75-86). Performance status: 0 3p, 1 8p, 2 10p, 3 1p. Gender: male 36.4%, female 63.6%. Stage IIIb 18.2%, IV 81.8%. 20p (90.9%) received therapy, all with a TKI (erlotinib, gefitinib or afatinib). The other 2p refused therapy. Median survival was 16 moths (m) (range 1-31). It was greater for patients with PS 0-1 (31m) and for females (32m) vs male (8m). No significant differences existed by stage or TKI. Lnadmark 2-year survival was 18.2% and 3-year 4.5%. These figures were lower than the corresponding for younger patients (median 21 months, 2-y 35.3%, 3-y 13.7).
Conclusion:
A significant percentage of NSCLC with EGFR mutation were older than 75 years. They tended to be more females and slightly worse PS than youger patients. Survival was also lower. These patients merit an specific approach, careful evaluation and follow-up.
