Author of

• 18975

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  P3.01 - Advanced NSCLC (ID 621)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23891

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    P3.01-032 - Preliminary study of  Lung Cancer Adenocarcinoma  with De-novo EGFR T790M Mutation in Persahabatan Hospital-Jakarta, Indonesia. (ID 9179)

    09:30 - 09:30  |  Author(s): A.C. Putra
    • Abstract

    Background:
    De-novo EGFR T790M mutations are rare, occurs less than 5% in the world and resistant to EGFR-TKI treatment. In Persahabatan Hospital, patients with De novo EGFR T790M mutations are given systemic chemotherapy with or without radiotherapy. No data on clinical profiles and 6 months survival rate in this group. the purpose of this preliminary study is to evalaute clincal profiles and 6 months survival of EGFR-T790M mutation in lung adenocarcinoma in Persahabtan Hospital Jakarta Indonesia.
    
    Method:
    Subjects was recruited consecutively from lung cancer Adenocarcinoma with De-novo EGFR T790M mutations. EGFR mutation is routinely assesed in lung adenocarcinoma in Persahabatan Hospital using PCR-High Resollution Melting, RFLP Analysis and direct sequencing. Subjects' clinical characteristics (race, age, gender), smoking habits, family history of malignancy, occupation, date at diagnosis (through anatomic pathology examination), complete diagnosis, stage, performance status, metastasis, chemotherapy and radiotherapy, RECIST evaluation, date of death were recorded.
    
    Result:
    Fourteen subjects were elligible and included in this study of which 9 subjects were male (64,2%), 5 subjects female (35,7%). Smoking status were 8 subject were smoker (57,1%), never smoke (35,7%), ex smokers (7,14%). Two subjects ( 14.2%) has family history of malignancy. All subjects were stage 4 with 42.8% pleural effusion (6 subjects), 21.4% pleural effusion and bone metastasis (3 subjects), 21.4% ( 3 subjects) with distant lymph nodes metastasis, 7.2% brain metastasis ( 1 subjects), 7.14% brain and bone metastasis. Mutation in ONLY exon 20 T790M 85,7% ( 12 subjects); double mutation did exist with Exon 19 ins/del and exon 20 T790M (1 subject); exon 19 ins/del and exon 20 T790M (1 subject); exon 21 L861Q and exon 20 T790M in 1 subject. Systemic chemotherapy were done in 9 subjects (64,3%), systemic chemotherapy and radiotherapy were done in 5 subject (35,7%). Six months survival rates in this group was 50%; and 1 year survival were 21,42%; Interestingly 4 subjects (28,6%) survived more than 1 year.
    
    Conclusion:
    De-novo EGFR T790M mutations are rare (< 5%). The presence double mutation ie. De-novo EGFR T790M mutations and other activating EGFR mutation did exist. these group has variable clinical responses with chemotherapy and warrant further investigation.