Author of

• 18975

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  P3.01 - Advanced NSCLC (ID 621)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23869

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    P3.01-010 - High Probability and Frequency of EGFR Mutations in Non-Small Cell Lung Cancer with Brain Metastases (ID 8394)

    09:30 - 09:30  |  Author(s): X. Zhou
    • Abstract
    • Slides

    Background:
    Lung cancer is the leading cause of cancer death in men and women worldwide. Brain metastasis (BMs) of NSCLC is the most important cause of death. This study aimed to explore the association of epidermal growth factor receptor (EGFR) mutations and brain metastases (BMs) in non-small cell lung cancer (NSCLC).
    
    Method:
    We analyzed 50 NSCLC patients with BMs and 50 match-paired NSCLC patients with no brain metastases (NBMs). The EGFR mutation status of primary lesions was detected using the amplification refractory mutation system (ARMS) polymerase chain reaction.
    
    Result:
    The BMs patients had a higher frequency of EGFR mutations than the NBMs patients (52.0% vs. 22.0% respectively, P＜0.001), in both adenocarcinoma (60.5% vs 30.6%, P=0.003) and squamous carcinoma (37.5% vs. 0%, P=0.04). The incidence of BMs in patients with EGFR mutations was higher than in patients with wild-type EGFR (70.3% vs. 38.1%, P=002).
    
    Conclusion:
    NSCLC patients with BMs had a higher incidence of EGFR mutations and those with mutant EGFR had a higher frequency of BMs. EGFR mutations may promote brain metastasis growth of NSCLC.
    
    

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