Author of

• 20180

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  P2.16 - Surgery (ID 717)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23536

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    P2.16-005 - Is There Any Oncological Concern about Preoperative Biopsy for Resectable Lung Cancer Patients? (ID 8708)

    09:30 - 09:30  |  Author(s): H. Matsui
    • Abstract
    • Slides

    Background:
    Preoperative trans-bronchial biopsy and/or computed tomography (CT)–guided biopsy inevitably disrupt lung structure and might disseminate tumour cells into airway, vessels or the pleural cavity. Because preoperative diagnostic intervention may potentially disperse tumour cells, it may affect relapse and/or prognosis.
    
    Method:
    The data from the consecutive patients with cTanyN0M0 lung cancer who underwent surgery between January 2006 and December 2012 at our institute were extracted by chart review and analysed retrospectively. Prognostic factors of overall and recurrence-free survival were compared among the groups (the trans-bronchial biopsy group, the CT-guided biopsy group and the intra- or postoperative-diagnosis group) by using the univariate and multivariate Cox proportional hazard model. A stepwise backward elimination method with a probability level of 0.15 was used to select the most powerful sets of outcome predictors. A p-value <0.05 was considered statistically significant.
    
    Result:
    Data from 397 patients were available for analysis (the trans-bronchial biopsy group: 221, the CT-guided biopsy group: 71 and the intra- or postoperative-diagnosis group: 105). Solid tumour size was larger in the trans-bronchial biopsy and/or the CT–guided biopsy than the intra- or postoperative-diagnosis group (p = 0.0001). In the crude analysis, the trans-bronchial biopsy group and the CT-guided biopsy group showed higher probability of pleural dissemination (p = 0.048) and showed worse prognosis than the intra- or postoperative-diagnosis group (overall survival: p = 0.0458, recurrence-free survival: p = 0.0101). However, the method of diagnosis was not identified as an independent risk factor for pleural dissemination and overall and recurrence-free survivals by multivariate analyses. Figure 1
    
    
    
    Conclusion:
    Preoperative diagnostic intervention did not affect relapse and/or prognosis in this study cohort. Preoperative diagnostic intervention is recommended if necessary.
    
    

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