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M.C.D. Oliveira
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P2.10 - Nursing/Palliative Care/Ethics (ID 711)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Nursing/Palliative Care/Ethics
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.10-006 - Prognostic Factors of Mortality and Recurrence of Malignant Pleural Effusion in High-Risk Tumors According to the LENT Score Study (ID 9635)
09:30 - 09:30 | Author(s): M.C.D. Oliveira
- Abstract
Background:
The aim of this study was to identify predictors of overall survival (OS) and recurrence after palliative pleural procedures in patients with malignant pleural effusion (MPE) and high-risk tumors according to the LENT Score Study.
Method:
Data was collected from our database between January 2013 and December of 2015 of patients high-risk tumors according to the LENT Score and MPE. All patients were followed-up at least 30 days after the pleural procedure. We studied radiological aspects, biochemical and hematimetric parameters beyond clinical features. To analyze OS, patients were divided into two groups. Group I included OS greater than 30 days and Group II included OS shorter than 30 days. Prognostic factors for pleural recurrence and OS were identified by univariate analysis, using Fisher's exact and Student's T-Test. Subsequently, the significant variables were entered into a multivariate logistic regression analysis (p < 0.05).
Result:
A total of 134 patients were included in the analysis. Median follow-up time for surviving patients was 56 (range 2 to 623) days. High-risk primary tumors included lung 66,4%, gastrointestinal 24,6%, sarcoma 3,7%, urological 3,7% and others 1,5%. There were 44 patients in Group I who had OS shorter than 30 days. Recurrence occurred in 22 patients of the entire cohort. Factors affecting OS in univariate analysis were: procedure, ECOG, albumin, leukocytes, neutrophil to lymphocyte ratio (NRL) e hemoglobin in peripheral blood. Factors affecting recurrence were: procedures, quimiotherapy line (QL), albumin and platelets. At the multivariate analysis in Group I, the type of procedure (therapeutic pleural aspiration – TPA) (p = 0.011), ECOG 3 e 4 (p = 0.004), NLR > 5 (p = 0.037) and leukocytes > 8000 (p = 0.042) were identified as independents predictors of OS. About recurrence, only QL further than first line (p = 0.042) was identified as independent predictor.
Conclusion:
Patients with MPE who underwent TPA, ECOG 3 and 4, with leukocytes > 8000, NLR > 5 were significantly associated with shorter OS, and QL greater than first line was associated with recurrence. The identification of those prognostic factors may assist the choice of the optimal palliative technique for high-tumors risk patients according LENT score study.
