Author of

• 20169

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  P2.05 - Early Stage NSCLC (ID 706)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23363

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    P2.05-020 - Prognostic Factors in Patients with Completely Resected Subsolid Node-Negative Lung Adenocarcinoma of 3cm or Smaller (ID 10398)

    09:30 - 09:30  |  Author(s): W. Hsu
    • Abstract

    Background:
    The operative method in ground glass pulmonary nodules is controversial. The prognostic value of histological subtypes in resected node-negative small-sized lung adenocarcinoma has not been widely investigated. This study aim to investigate the prognostic factors in patients with resected small ground glass nodules with consolidation/tumor (C/T) ratio of 0.5 or less determined by chest computed tomography.
    
    Method:
    A total of 377 patients with completely resected node-negative lung adenocarcinoma of 3cm or smaller and C/T ratio of 0.5 or less were included in the study. Prognostic factors for overall survival (OS) or probability of freedom from recurrence (FFR) were investigated.
    
    Result:
    The 5-year OS and probability of FFR were 93.7% and 91.5%, respectively. During follow-up, 15 (4.0%) patients developed recurrence. Univariate analysis showed that order age (P = 0.008) and greater tumor size (P = 0.008) had significantly worse OS. Patient underwent sublobar resection had significantly worse OS than those with lobectomy (P = 0.003). Greater tumor size (P = 0.006) and sublobar resection (P = 0.002) were still significant prognostic factors for worse OS in multivariate analysis. Univariate analysis showed that order age (P = 0.007), greater tumor size (P = 0.001), and micropapillary/solid predominant group (P = 0.002) had significantly lower probability of FFR. Operative method (sublobar resection vs. lobectomy) was not a significant prognostic factor for FFR (P = 0.726). Older age (P = 0.016), greater tumor size (P = 0.026), and micropapillary/solid predominant group (P = 0.043) still had significantly lower probability of FFR in multivariate analysis.
    
    Conclusion:
    For patients with completely resected node-negative lung adenocarcinoma of 3cm or smaller and C/T ratio of 0.5 or less, greater tumor size was a poor prognostic factor for both OS and probability of FFR. Sublobar resection was a significant prognostic factor for worse OS, but not probability of FFR. The new adenocarcinoma histopatholofgical classification has significant impact on recurrence in these patients.