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C. Labbé
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P2.05 - Early Stage NSCLC (ID 706)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.05-019 - Overall Survival (OS) of Pathological T1N0 Non-Small Cell Lung Cancer (NSCLC) After Resection. (ID 10294)
09:30 - 09:30 | Author(s): C. Labbé
- Abstract
Background:
Complete surgical resection is the standard treatment of stage I NSCLC. The aim of the current study was to evaluate overall survival of T1N0 NSCLC after complete resection.
Method:
The Institut de Cardiologie et Pneumologie de Quebec Biobank was queried for all patients with pathological T1N0M0 NSCLC who underwent complete (R0) surgical resection between November 1999 and February 2017. Survival was examined using the Kaplan-Meier method with log rank analysis. Significance was set at p≤0.05.
Result:
We identified 1071 eligible patients, 624 (58%) were female with mean age of 64±9y, 763 (71%) were adenocarcinoma and 183 (17%) were squamous cell carcinoma. Regarding surgical modality, 285 (27%) patients underwent sublobar resection, 772 (72%) lobectomy or bilobectomy and 14 (1%) pneumonectomy. The 30-day mortality of the cohort was 0.3% (3 patients). During 17 years of follow-up, a total of 253 (24%) patients died; of these events, 160 (63%) were cancer-related. Median OS of the cohort was 12.8y (CI 11.2 – 14.2). When comparing lobar versus sublobar resection, median OS was 12.8y and 8.7y respectively (HR 1.92; CI 1.45-2.55, p=<0.0001) (Figure 1). Figure 1: Overall survival according to type of resection Figure 1
Conclusion:
In our institutional database study, median OS after complete resection of T1N0 NSCLC was 12.8y. Patient undergoing lobectomy had a survival advantage over patients who had sublobar resection. Until more definitive data confirms our findings, patients with T1N0M0 disease should be treated with lobectomy.
