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H. Yamamoto
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P2.05 - Early Stage NSCLC (ID 706)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.05-010 - Changes between Pre- and Post-Operative AICS (Lung) in NSCLC Patients: Predictability of High-Risk Cases with Recurrence (ID 7915)
09:30 - 09:30 | Author(s): H. Yamamoto
- Abstract
Background:
Plasma free amino acid (PFAA) levels are known to change in patients with malignant diseases. We have developed AminoIndex[TM] Cancer Screening (AICS[TM]) using “AminoIndex Technology”, which is a multivariate analysis of PFAA concentrations in various cancer patients and healthy controls. In Japan, AICS[TM] is now commercially available for simultaneous screening of seven cancer types, including lung cancer. The lung cancer specific AICS [AICS (lung)] are classified as rank A (AICS values: 0.0–4.9), rank B (5.0–7.9), or rank C (8.0–10.0); the closer to rank C, the higher risk of lung cancer. The aim of this study was to evaluate post-operative changes of AICS (lung) in patients who underwent curative surgical resection for lung cancer, as well as the associations of these changes with post-operative cancer recurrence.
Method:
The subjects were lung cancer patients with pre-operative AICS (lung) rank B-C, 44 patients (rank C; 29 cases, B; 15 cases) who underwent surgical curative resection. The pathological stage was 29 stage I, 8 stage II and 7 stage III. AICS (lung) was measured within 1 week prior to surgery and from 1.2 to 5.5 years after surgery, and the relationship between fluctuation before and after surgery and post-operative recurrence was analyzed.
Result:
Post-operative AICS (lung) ranks and values decreased in 52% (23/44) and 82% (36/44), respectively. For the pre-operative AICS (lung) rank C patients, post-operative AICS (lung) ranks and values decreased in 52% (15/29) and 86% (25/29), respectively. All 12 patients who had recurrence had a pre-operative AICS (lung) rank C. Among the 7 patients had recurred at the time of post-operative AICS (lung) measurement, 6 patients remained AICS (lung) rank C after surgery and 1 patient was rank B after surgery. On the other hand, among 5 patients in which recurrence was observed after post-operative AICS (lung) measurement, 4 patients remained post-operative AICS (lung) rank C and only 1 patient was rank B.
Conclusion:
Most patients had a decrease in the AICS (lung) rank and value after curative surgical resection. However, ten of 15 patients who had both pre- and post-operative AICS (lung) rank C had recurrence after surgery, suggesting the association between pre- and post-operative change in AICS (lung) and recurrence after lung cancer surgery. Pre- and Post-operative AICS (lung) measurement may be able to predict high-risk cases with post-operative cancer recurrent.
