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A.L. Huswatun
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P2.03 - Chemotherapy/Targeted Therapy (ID 704)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Chemotherapy/Targeted Therapy
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.03-031 - Efficacy of Gefitinib and Radiotherapy Combination in Lung Adenocarcinoma (ID 9160)
09:30 - 09:30 | Author(s): A.L. Huswatun
- Abstract
Background:
Combinations of gefitinib and radiotherapy have been observed to have synergistic and anti-proliferative effects on lung cancer in vitro, but clinical studies were limited. In clinical setting, patients who presented with respiratory difficulties like SVCS, radiotherapy should be given immediately to address the emergency while waiting for the results of EGFR mutation test.
Method:
We did a preliminary study to evaluate the efficacy of gefitinib and radiotherapy combination in lung adenocarcinoma in Persahabatan National Respiratory Refferal Hospital Jakarta Indonesia. Subjects were consecutively recruited between January 2013 to December 2016
Result:
Thirty one lung adenocarcinoma with EGFR mutations were enrolled. Most of them were male (51.61%) with median age of 54.5 years old (range 38-70 years old). Epidermal Growth Factor Reseptor (EGFR) mutation characteristics were on exon 21 L858R (61.30%); exon 21 L861Q (16.12%) and exon 19 deletion (22.58%). Radiotherapy were given at doses between 30-60 Gy. Among these subjects, Progression Free Survival (PFS) were 185 days (CI95%; 123.69-246.30), 1 year survival rate (1-ysr) was 45.2%. and overall survival (OS) are 300 days (CI95%;130.94-469.06). There were no grade 3/4 hematological and non hematological toxicities recorded. The most frequent Grade 1 and 2 non hematological toxicities were skin rash, diarrhea, paranochia and monoliasis and might be related to TKI.
Conclusion:
The combination of TKI with radiation may be considered in subjects with respiratory distress.
