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C. Konaka
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P2.03 - Chemotherapy/Targeted Therapy (ID 704)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Chemotherapy/Targeted Therapy
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.03-007 - Loxoprofen Prevents EGFR-TKI-Related Skin Rash in Non-Small Cell Lung Cancer Patients: A Single-Center Retrospective Study (ID 7539)
09:30 - 09:30 | Author(s): C. Konaka
- Abstract
Background:
Skin rash is the most common adverse event induced by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). The efficacy of tetracycline for EGFR-TKI-related skin rash has been reported. However, a skin rash is often observed despite the use of tetracycline. Some studies have reported that skin rash is caused by a type of inflammation. Hence, there is a possibility that loxoprofen, a non-steroidal anti-inflammatory drug, can prevent these skin rashes.
Method:
We conducted a single-center, retrospective study to investigate the efficacy of loxoprofen for EGFR-TKI-related skin rash. The patients had non-small cell lung cancer and received EGFR-TKIs at the Chemotherapy Research Institute, Kaken Hospital from October 2011 to March 2017. We divided them into two groups: those who received EGFR-TKIs along with loxoprofen (loxoprofen (+) group; n = 12) and without loxoprofen (loxoprofen (−) group; n = 37), and investigated the incidence of EGFR-TKI-related skin rash.
Result:
There was no significant difference in the baseline characteristics between the groups. Grade 1 and 2 EGFR-TKI-related skin rash were more common in the loxoprofen (−) group than in the loxoprofen (+) group (grade 1; 90% versus 60%, P = 0.007, grade 2; 50% versus 0% P = 0.043, log-rank analysis). Multiple regression analysis indicated that the use of loxoprofen was a predictive factor that reduced the incidence of grade 1 skin rash (P = 0.0046). Figure 1
Conclusion:
Our study showed that loxoprofen combined with EGFR-TKIs could prevent skin rash, decreasing the risk by more than 65%. Our results suggest that loxoprofen can prevent and treat EGFR-TKI-related skin rash. Thus, we conclude that loxoprofen could be a new treatment option for EGFR-TKI-related skin rash.
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P2.16 - Surgery (ID 717)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.16-012 - Does Percutaneous Ultrasound Predict Tumor Site and Internal Tumor Properties? (ID 9493)
09:30 - 09:30 | Author(s): C. Konaka
- Abstract
Background:
The lung contains a large volume of air and have thus been unsuitable for observation with ultrasound. However, recent advancements in ultrasound have enabled the diagnosis of pneumothorax and tumor invasion of the chest wall, and fine-needle aspiration of tumors abutting the pleura can now be performed using ultrasound. Here, we investigated whether ultrasound is capable of predicting internal tumor properties.
Method:
TOSHIBA aplio 400 was used. Of 64 patients with tumor lesions undergoing preoperative ultrasound at our hospital between June 2015 and April 2017, we investigated 42 patients in whom internal tumor properties were visualized before surgery. There were 27 men and 15 women; 37 patients had malignant and 5 had benign lung tumors. Solid components were present in the tumor in 25 patients, liquid components in 3, a cavernous lesion in 9, a ground-glass opacity (GGO) lesion in 4, and pulmonary sequestration in 1. The tumor diameters ranged from 0.7 to 10.4 cm (median, 2.4 cm), and the distances from the lung surface ranged from 0 to 8.9 cm (median, 0.57 cm).
Result:
Ultrasound was useful for identifying an anomalous vessel originating from the aorta in a case with pulmonary sequestration. According to internal tumor properties, lesions containing a large volume of air (cavernous or GGO lesions) were visualized as hyperechoic areas, while many solid lesions appeared hypoechoic with a hyperechoic periphery on images. The posterior echo was enhanced in tumors containing liquid components and also in many cases with benign tumors. Thus, ultrasound is potentially useful for determining whether tumors are malignant or benign before surgery.
Conclusion:
Although ultrasound was not capable of visualizing the internal tumor structures in all cases, the internal tumor structure, if visualized by ultrasound, could be assessed. Moreover, ultrasound has the potential for differentiating benign from malignant tumors. Our results suggest that ultrasound merits future study, with further accumulation of cases.
