Author of

• 18972

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  P2.02 - Biology/Pathology (ID 616)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Biology/Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23258

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    P2.02-060 - Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma (ID 9109)

    09:30 - 09:30  |  Author(s): D. Jeong
    • Abstract

    Background:
    Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), is a secreted glycoprotein associated with endothelial cell surface and extracellular matrix. Overexpressed EDIL3 can contribute to carcinogenesis by promoting cancer vascularization and epithelial–mesenchymal transition. Therefore, EDIL3 might be a good candidate target for developing novel cancer anti-angiogenic therapy. Although the associations among EDIL3, mesenchymal phenotype, and angiogenesis have been observed in several malignancies, no study has examined the relationships among EDIL3, mesenchymal phenotype, and angiogenesis or the prognostic significance of EDIL3 expression in non-small cell lung carcinoma (NSCLC) patients. We examined the prognostic significance of EDIL3 expression and its correlations with mesenchymal phenotype and microvessel density in NSCLC.
    
    Method:
    A total of 268 NSCLC specimens were evaluated retrospectively by immunohistochemical staining for EDIL3, epithelial–mesenchymal transition (EMT) markers (e-cadherin, β-catenin, and vimentin), and CD31 to measure microvessel density. we performed real-time qRT PCR for EDIL3 expression
    
    Result:
    EDIL3, e-cadherin, β-catenin, and vimentin were expressed in 16%, 22.8%, 3.7%, and 10.1% of the specimens, respectively. The mRNA level of EDIL3 in tumor was correlated with the level of EDIL3 protein expression using immunohistochemistry. In lung adenocarcinoma patients, EDIL3 expression was significantly correlated with mesenchymal phenotype (low e-cadherin expression and high vimentin expression) and increased microvessel density (P < 0.001, P = 0.001, and P = 0.023, respectively). In lung squamous cell carcinoma patients, EDIL3 expression was significantly correlated with mesenchymal phenotype (low e-cadherin expression and high vimentin expression) (P = 0.021 and P = 0.002, respectively). In lung adenocarcinoma patients, EDIL3 was an independent prognostic factor for overall survival in a multivariate analysis (hazard ratio: 2.552, P = 0.004).
    
    Conclusion:
    EDIL3 is significantly correlated with mesenchymal phenotype, angiogenesis, and tumor progression in lung adenocarcinoma.