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P. Aukrust
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P2.02 - Biology/Pathology (ID 616)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.02-053 - The Prognostic Value of 18 Circulating Markers of Inflammation, Endothelial Activation and<br /> Extracellular Matrix Remodelling in Non-small Cell Lung Cancer Patients (ID 8302)
09:30 - 09:30 | Author(s): P. Aukrust
- Abstract
Background:
The aim of the study was to assess the prognostic value of 18 proteins as markers of inflammation and fibrosis (Table 1) in surgically treated non-small cell lung cancer patients and how the chronic obstructive pulmonary disease (COPD) as co-morbidity affected the prognostic significance.
Method:
Blood samples were collected from 207 lung cancer patients with an early-stage disease before surgery. 55,6% of the lung cancer group had COPD and the majority of these (86%) had moderate COPD (GOLD 2). We grouped the lung cancer patients with moderate, severe and very severe COPD (GOLD 2,3 and 4) in one group, and the lung cancer patients with mild (GOLD 1) or no COPD in another group. Serum levels of 18 proteins were measured by enzyme immunoassays. The proteins were selected because most were previously known to be associated with lung cancer and its prognosis, some with COPD.
Result:
Higher soluble tumour necrosis factor (TNF) receptor type 1 (sTNFR1) level was associated with better overall survival (OS) and progression-free survival (PFS) for lung cancer patients with COPD (OS p=0.006 and PFS p=0.030) and without COPD (OS p=0.040). High level of C-reactive protein (CRP) was significantly associated with poor overall survival regardless of COPD status. Higher osteoprotegerin (OPG) level was significantly associated with better PFS (p=0.014) and OS (p=0.027) in patients with lung cancer and COPD. In lung cancer patients with COPD, only CRP was significantly increased compared to patients without COPD of those three proteins.
Conclusion:
Whereas high levels of sTNFR1 and OPG, members of the TNF receptor superfamily, were associated with better prognosis, high level of CRP was associated with worse prognosis. This illustrates the complex role of inflammation and TNF-related molecules, particularly in the prognosis of non-small cell lung cancer, at least partly influenced by COPD as co-morbidity.
