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J.E. Kwon
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P2.02 - Biology/Pathology (ID 616)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.02-029 - Morphologic Features of Lung Adenocarcinoma Expressing PD-L1 Protein in Small Biopsy Specimens (ID 8492)
09:30 - 09:30 | Author(s): J.E. Kwon
- Abstract
Background:
In patients with resected non-small cell lung cancer, the relationships between PD-L1 expression and various clinicopathological characteristics have been examined. However, the association between cytological features and PD-L1 expression to the authors’ knowledge remains unknown. In the current study, the authors used small biopsy specimens to investigate whether morphologic feature correlated with PD-L1 expression in patients with advanced and inoperable lung adenocarcinoma.
Method:
Archival slides from ninety patients with lung adenocarcinoma who underwent small biopsy between October 2014 and May 2017 at Incheon St. Mary’s Hospital were reviewed. The small biopsy specimens were obtained from lung (52 cases), pleura (16 cases), lymph node (13 cases), brain (8 cases), and bone (1 cases). PD-L1 expression was detected by immunohistochemistry using the PD-L1 22C3 IHC assay. We examined the association of PD-L1 expression with pathological and molecular features (EGFR mutation, ALK and ROS-1 rearrangement) and was statistically correlated with histological characteristics.
Result:
PD-L1 expression in tumor cells was positive in 33 of 90 cases (36.7%). Higher PD-L1 expression (≥50%) was more frequent in marked nuclear pleomorphism (p<0.001), coarse chromatin pattern (p=0.006), predominant nucleoli (≥3μm)(p< 0.001), large nuclear diameter (>5 small lymphocytes) (p= 0.006), non-glandular feature (p<0.001) and atypical mitosis (p=0.034). There were no significant correlations between PD-L1 positivity and molecular features. In a multivariable logistic regression analysis, PD-L1 positivity was independently associated with prominent nucleoli (multivariable odds ratio, 6.688; 95% confidence interval [CI], 1.784–25.065; P = 0.005) and non-glandular feature (multivariable odds ratio, 4.539; 95% confidence interval [CI], 1.508–13.663; P = 0.007).
Conclusion:
Our study demonstrated that PD-L1 expression was associated with prominent nucleoli and non-glandular feature in lung adenocarcinoma, which might lead to a poor prognosis.
