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Y. Ma



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    P2.01 - Advanced NSCLC (ID 618)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P2.01-068 - Lobectomy Improve the Survival of Non-Small Cell Lung Cancer Patients with Occult Malignant Pleural Disease First Detected at Thoracotomy (ID 9131)

      09:00 - 09:00  |  Author(s): Y. Ma

      • Abstract
      • Slides

      Background:
      To aim of this study was to determine the clinical and biological prognostic factors for occult malignant pleural disease (MPD) first detected at thoracotomy in patients with non-small cell lung cancer (NSCLC) and evaluate the results of surgical intervention.

      Method:
      A total of 123 patients diagnosed with MPD at consecutive 2894 thoracotomy from January 2006 to October 2016. Clinical and pathological characteristics were evaluated in 120 patients. Survival curves were estimated by the Kaplan–Meier method, and Cox regression analysis was performed to validate the selected risk factors.

      Result:
      With a median follow-up of 34 months, the 5-year overall survival of 120 patients was 28%. Multivariate analyses using the Cox proportional hazards model showed gender (p=0.066), T stages (p<0.001), N stages (p=0.032), pleural invasion in image (p=0.004), pleural effusion (p=0.027), surgery intervention (p=0.024) and EGFR status (p=0.001) were independent predictors of survival. The 5-year survival rate and median survival time (MST) for 21 patients with lobectomy were 71.6% and 62.6 months, compared with 25.6% and 40.0 months in 46 patients with sublobectomy. When 53 patients subjected to open-close surgery, their 5-year survival rate and MST were 23.4% and 30.2 months. There was significant prognostic difference between lobectomy and sublobectomy /open-close surgery (p=0.033/0.016), but no significant difference was found between sublobectomy and open-close surgery (p=0.679) Figure 1



      Conclusion:
      Lobectomy confers better prognosis compared to sublobectomy and exploratory thoracotomy for occult MPD patients with NSCLC.

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