Author of

• 18973

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  P2.01 - Advanced NSCLC (ID 618)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:00 - 16:00, Exhibit Hall (Hall B + C)

  • 23151

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    P2.01-028 - Clinical Correlation between CTCs Enumeration Based on New Detection Method and Chemotherapy Efficacy in  Human Advanced Lung Cancer (ID 8926)

    09:00 - 09:00  |  Author(s): H. Chen
    • Abstract
    • Slides

    Background:
    Increasing emerging studies on circulating tumor cells (CTCs) suggest that CTCs become more and more important in tumor area. However, the difficulty in isolating and enriching CTCs from the billions of blood cells in peripheral blood restricts its development. Recently, we found a new method with high sensitivity and efficiency for CTCs detection. This study aimed to utilize a new method to evaluate the correlation with the CTCs enumeration and chemotherapy efficacy in the human lung cancer patients with stage III or stage IV.
    
    Method:
    Blood samples collected from 38 patients with advanced lung cancer before and after treatment were conducted to detect CTCs by new magnetic nanospheres with prominent magnetic/fluorescence properties (Fig.1), which was different from CellSearch. The information of CTCs enumeration was recorded and analyzed with respect to after and before chemotherapy, and clinicopathological features. Figure 1
    
    
    
    Result:
    High level of CTCs number was found in 15 of 38(39.5%) samples with advanced lung cancer, and it related with stage (p=0.030) and metastasis (p=0.030). Our results suggested that CTCs enumeration could be a marker in reflecting the efficacy of chemotherapy in cases of partial responses (P=0.046) and progressive disease (P <0.001). There was no significant difference in stable disease group (p=0.549).
    
    Conclusion:
    This nanosphere-based one-step strategy enables viable CTC detection. These findings showed the change of CTCs enumeration could reflect efficacy of chemotherapy, providing an easier method to evaluate and adjust promptly therapy regimen.
    
    

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