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H. Liu



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    P2.01 - Advanced NSCLC (ID 618)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
    • +

      P2.01-019 - The Necessity of Contrast-enhanced CT before CT-Guided Percutaneous Transthoracic Needle Biopsy for Lung Lesions (ID 8392)

      09:00 - 09:00  |  Author(s): H. Liu

      • Abstract

      Background:
      To evaluate the effect of pre-biopsy contrast-enhanced CT scanning on hemorrhage complicating percutaneous transthoracic needle biopsy

      Method:
      This retrospective study was approved by the institutional review board. We reviewed 1282 biopsy procedures, Chi-square test and multivariate analysis. We conduct propensity score matching by using MatchIt package in R with nearest-neighbor 1-to-1, 2-to-1 and 3-to-1 matching ,respectively

      Result:
      The incidence of pulmonary hemorrhage was 20.2% (259/1282), including 247(19.2%) mild hemorrhage, 7 (0.5%) moderate hemorrhage, and 5 (0.4%) severe hemorrhage. Pre-biopsy CECT scan was significantly associated with pulmonary hemorrhage, and had a positive effect (p=0.008, OR=0.671, 95% CI: 0.499-0.902). When matching hemorrhage and non-hemorrhage cases in proportion of 1 to 1, 1 to 2, and 1 to 3, the correlation of CECT and hemorrhage showed significancy and CECT was indeed a protective factor (p=0.039, 0.028 and 0.013, respectively). Additionally, biopsy position (p=0.016,OR=2.734, 95% CI: 1.207-6.194 for supine, lateral as reference), lesion sizes (p=0.005, OR=0.990, 95% CI: 0.983-0.997), puncture depth (P=0.000, OR=1.017, 95% CI: 1.009-1.025), number of pleural passes (P<0.05, for twice, third, fourth, OR= 1.546, 1.673, 8.746, 95% CI: 1.065-2.244, 1.082-2.588, 2.891-26.456, respectively ) were also related with hemorrhage.

      Conclusion:
      Pre-biopsy contrast-enhanced CT scan is a protective factor for hemorrhage. To reduce the incidence of hemorrhage to the greatest extent. We strongly suggest the patients scheduled to perform percutaneous transthoracic needle biopsy do pre-biopsy contrast-enhanced CT scan routinely.