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R.N. Kubota



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    P1.17 - Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies (ID 703)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Thymic Malignancies/Esophageal Cancer/Other Thoracic Malignancies
    • Presentations: 1
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      P1.17-010 - The Diagnostic Value of Serum Cytokeratin Fragment 19 (CYFRA21-1) for Thymic Squamous Cell Carcinoma (ID 9407)

      09:30 - 09:30  |  Author(s): R.N. Kubota

      • Abstract

      Background:
      Preoperative diagnosis of anterior mediastinal tumor has been depending on the radiographic findings and clinical findings. We investigated the diagnostic value of serum tumor markers in patients with anterior mediastinal tumor.

      Method:
      Consecutive anterior mediastinal tumor patients referred to our hospital who had examined either of the serum tumor markers (CEA, SCC, CYFRA 21-1) preoperatively and underwent radical surgery or surgical biopsy between January 1999 and February 2016 were retrospectively reviewed.

      Result:
      One hundred eighteen patients were eligible, including 16 thymic carcinomas, 48 thymomas, 11 lymphomas, 13 mature teratomas, 7 other malignant tumors, 23 other benign legions. Preoperative serum CYFRA 21-1 was significantly higher in thymic carcinoma group (median = 2.4 ng/ml) than other anterior mediastinal tumor group (median = 1.1 ng/ml, p = 0.0005), whereas CEA (median 2.0 vs 2.1) and SCC (median 0.7 vs 0.8) showed no significant difference. The ROC curves identified an optimal serum CYFRA 21-1 cut off value of 1.65 ng/ml for predicting the diagnosis of thymic carcinoma (AUC = 0.80; sensitivity = 76.9%, specificity = 79.3%; P = 0.046). Pre- and post operative serum CYFRA 21-1 were measured in 6 patients who underwent radical resection. All those patients showed decrease of serum CYFRA 21-1 after resection.

      Conclusion:
      To measure serum CYFRA 21-1 may help the diagnosis of thymic carcinoma. The level of CYFRA 21-1 reflected the condition of the tumor in each patients. The optimal serum CYFRA 21-1 cut off value for predicting the diagnosis of thymic carcinoma was 1.65 ng/ml.