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C. Ng
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P1.16 - Surgery (ID 702)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.16-013 - Video-Assisted Thoracoscopic Surgery (VATS) versus Thoracotomy in Locally-Advanced Lung Cancers – a Meta-Analysis (ID 9231)
09:30 - 09:30 | Author(s): C. Ng
- Abstract
Background:
Video-assisted thoracoscopic surgery (VATS) has been established as the preferred approach for surgical resection of early-stage non-small cell lung cancers. It is shown to have improved oncological outcomes with lower perioperative complication rates when compared with conventional open lobectomy. However, there is a paucity of high-level evidence supporting its use in locally-advanced lung cancers. Moreover, published results have shown contrasting outcomes. We conducted a meta-analysis to compare oncological outcomes as well as perioperative complications for VATS versus conventional thoracotomy in this population.
Method:
Electronic databases (PubMed MEDLINE, EMBASE and Web of Science) were searched for studies evaluating VATS versus conventional thoracotomy for the resection of locally-advanced lung cancers. Individual outcome data was pooled to investigate the summary effect.
Result:
A total of 5 studies comparing the two approaches were identified. Of these, only 3 studies reported long-term survival data appropriately and were analysed separately. There was no difference in 3-year overall survival (HR 0.67, 95% CI 0.29-1.53) or 3-year disease-free survival (HR 1.09, 95% CI 0.77-1.55) when comparing VATS against open thoracotomy. However, VATS was associated with a shorter length of stay (2.02 days, 95% CI 0.65-3.39 days). There was no difference in blood loss between the two approaches.
Conclusion:
Oncological outcomes of VATS resection appear to be at least equivalent to conventional thoracotomy in locally-advanced lung cancers. Length of stay is shorter for VATS, which has been shown to correlate with better cost-effectiveness. Ideally, randomised controlled trials should be designed to confirm and further investigate these conclusions.
