Author of

• 20164

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  P1.15 - SCLC/Neuroendocrine Tumors (ID 701)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: SCLC/Neuroendocrine Tumors
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22800

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    P1.15-015 - Prognostic Implication of the FEV1/FVC Ratio in Limited-Stage Small Cell Lung Cancer (ID 7873)

    09:30 - 09:30  |  Author(s): M. Chun
    • Abstract
    • Slides

    Background:
    The aim of this study was to evaluate whether the pretreatment forced expiratory volume 1 (FEV1)/forced volume vital capacity (FVC) ratio could predict survival in patients with limited-stage small cell lung cancer (LS-SCLC).
    
    Method:
    We assessed 74 patients with LS-SCLC treated with chemoradiotherapy who were divided into two groups: those with FEV1/FVC <0.74 (n=24) and those with FEV1/FVC ≥0.74 (n=50).
    
    Result:
    The 3-year overall survival (OS) and 3-year progression-free survival (PFS) rates were significantly lower in patients with FEV1/FVC ratios <0.74 than in those with ratios ≥0.74 group (35.4% vs. 61.2%, P=0.0033; and 11.7% vs. 51.8%, P=0.0072, respectively). On multivariate analysis, a low FEV1/FVC ratio was independently associated with OS and PFS (hazard ratio [95% confidence interval]: 2.15 [0.99–4.63], P=0.052; and 2.13 [1.04–4.39], P=0.039, respectively).
    
    Conclusion:
    The pretreatment FEV1/FVC ratio appears to be a potential prognostic factor for LS-SCLC.
    
    

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