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J. Chen
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P1.15 - SCLC/Neuroendocrine Tumors (ID 701)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: SCLC/Neuroendocrine Tumors
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.15-008 - Clinical Features and Gene Mutation Profiling of Pulmonary Carcinoid Tumors (ID 7440)
09:30 - 09:30 | Author(s): J. Chen
- Abstract
Background:
Carcinoid tumors of the lung are an uncommon group of pulmonary neoplasms. Carcinoid tumors represent the most indolent form of a spectrum of bronchopulmonary neuroendocrine tumors, however little is known about its molecular features. We analyzed pulmonary carcinoid tumors to identify biologically relevant genomic alterations.
Method:
We reviewed all the patient data from 2006 to 2016 in our hospital and collected 20 cases of lung carcinoid tumors. We summarized their clinical features and imaging data. Among 20 cases of lung carcinoid tumors, quality control was passed for 6 patients. We performed targeted capture sequencing of 56 cancer-related genes. Moreover, we made a literature review of pulmonary carcinoid tumors and summarized the clinical features and gene mutations.
Result:
Among the 20 pulmonary carcinoid tumors cases, which include 9 typical carcinoid and 11 atypical carcinoid tumors, there was a male predominance of this disease (Male vs Female: 15 vs 5). The range of age is 14 to 71 with the median age of 48. For gene mutation profiling on 6 pulmonary carcinoid tumors, we detected 27 mutations in 21 genes, including 22 missense mutations, 2 deletion mutations, 1 frameshift mutation and two others. Among the 21 genes, there are 11 proto-oncogenes and 6 tumor suppressor genes, which were reported to participate in the tumorigenesis, growth, invasion and metastasis of tumor.
Conclusion:
Through the next generation sequencing, we detected 27 mutations in 21 gene on the 6 pulmonary carcinoid tumors. Among these genes, the mutation of gene IGF1R, ERBB4, KIT and TSC2 showed the most frequent. We supposed that these genes might be involved in the tumorigenesis of pulmonary carcinoid tumors and the potential targets of therapy. Further functional studies of these genes are worthy of being explored.
