Author of

• 20163

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  P1.14 - Radiotherapy (ID 700)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Radiotherapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22778

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    P1.14-011 - An Esophagus-Sparing Technique to Limit Radiation Esophagitis in Locally Advanced NSCLC Treated by SIB-IMRT and Concurrent Chemotherapy  (ID 8090)

    09:30 - 09:30  |  Author(s): Y. Huang
    • Abstract
    • Slides

    Background:
    To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) and concurrent chemotherapy.
    
    Method:
    Ninety-five patients with stage IIIA/B NSCLC who received definitive SIB-IMRT and concurrent chemotherapy had been divided into two groups: 1.with esophagus sparing technique; 2.without esophagus sparing technique. Chi-square test was performed to compare sex, clinical stage, histology, concurrent chemotherapy, RE and nutrition status between two groups. T-test was used to compare the dosimetric parameters. Overall survival (OS) and loco-regional failure free survival (LRFS) were calculated by the Kaplan–Meier method and compared by a log-rank test.
    
    Result:
    There were 50 patients in the esophagus sparing group and 45 in the non-sparing group. The incidence of severe RE (Grade 3-5) was significantly lower in patients with esophagus sparing technique (p = 0.000). Patients in esophagus sparing group had better nutrition status (p = 0.029). With a median follow-up of 23 months (range 0-37 months), the 3-year OS of all the patients was 33.4%. OS time was found to be longer in the esophagus-sparing group (32 vs. 27 months, p= 0.010). LRFS was comparable between two groups (29 vs. 24 months, p=0.960).
    
    Conclusion:
    Esophagus-sparing technique is an effective and essential method to limit RE in LANSCLC treated by SIB-IMRT and concurrent chemotherapy. Reducing severe RE when escalating radiation fraction size may help to achieve higher local control and better general performance status.
    
    

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