Author of

• 20159

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  P1.10 - Nursing/Palliative Care/Ethics (ID 696)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Nursing/Palliative Care/Ethics
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22740

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    P1.10-005 - Generation of Symptom Burden Patient-Reported Outcomes for Patients with Lung Cancer (ID 8675)

    09:30 - 09:30  |  Author(s): O. Bamidele
    • Abstract

    Background:
    Systematic collection of patient experience of disease and treatment through validated patient-reported outcome measures (PROs) is recommended for research and practice. Symptom burden, the combined impact of disease- and therapy-related symptoms on daily functioning, is important to patients and appropriate for PRO measurement. PRO development should include literature reviews, patient input, and expert opinion for content domain specification and item generation. Our purpose is to describe initial development of symptom burden PROs for malignant pleural mesothelioma (MPM) and small-cell lung cancer (SCLC).
    
    Method:
    The MD Anderson Symptom Inventory (MDASI) Core is a 13-symptom-item (pain, fatigue, nausea, sleep disturbance, distress, shortness of breath, trouble remembering, appetite loss, drowsiness, dry mouth, sadness, vomiting, and numbness or tingling) and 6-functional-item (general activity, mood, work, relations with others, walking, enjoyment of life) PRO measuring cancer symptom burden. Additional symptoms for specific diseases and treatments can be added. We performed systematic literature reviews for symptoms of MPM and SCLC. We conducted open-ended interviews with 20 patients with MPM and 25 patients with SCLC about their disease and treatment experiences. Descriptive exploratory analysis identified symptoms. Expert panels of physicians, other healthcare providers, patients, and family caregivers rated the relevance of symptoms from patient interviews. Symptoms consistently found in literature, mentioned in ≥ 20% of interviews, or with mean relevance ratings of “relevant/very relevant” were added to the MDASI Core to form the MDASI-MPM and MDASI-SCLC.
    
    Result:
    For MPM: Literature review found 5 major symptoms, patient interviews identified 24 symptoms, and experts rated 13 symptoms “relevant/very relevant.” Five symptoms were added to the MDASI Core to make the MDASI-MPM. For SCLC: Literature review found 8 major symptoms, patient interviews identified 37 symptoms, and experts rated 20 symptoms “relevant” or “very relevant.” Nine symptoms were added to the MDASI Core to make the MDASI-SCLC. Lung cancer-specific symptoms common to the two groups are: coughing, muscle weakness, malaise, and trouble with balance or falling. The additional MPM symptom was chest tightness. Additional SCLC symptoms were dizziness, constipation, difficulty concentrating, headache, and foot swelling.
    
    Conclusion:
    Patient report of the experience of MPM or SCLC frequently includes symptoms and how those symptoms interfere with daily activities. The MDASI-MPM and MDASI-SCLC are undergoing psychometric testing and may be modified based on the results. They will be the only validated measures of the symptom burden of MPM and SCLC.