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Y. Chen



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    P1.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 692)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
    • Presentations: 1
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      P1.06-019 - The Association Between HPV Presence and EGFR Mutations in Asian Patients with NSCLC: A Meta-Analysis (ID 10108)

      09:30 - 09:30  |  Author(s): Y. Chen

      • Abstract
      • Slides

      Background:
      The etiology of non-smoking NSCLC remains largely unknown. It has been widely proved that human papillomavirus (HPV) participate in the development of various cancers unrelated to smoking. Epidermal growth factor receptor (EGFR) mutation patients represent a large part of non-smokers with NSCLC. We performed this meta-analysis to evaluate whether HPV infection in NSCLC tissue is associated with EGFR mutation compared with HPV negative controls.

      Method:
      MEDLINE, EMBASE, PubMed and Web of Science were searched through June 2017, using the search terms “lung cancer”, “human papillomavirus”, “HPV”, “epidermal growth factor receptor”, “EGFR” and their combinations. We included studies in which HPV detection was based on PCR methods. Association was tested using odds ratio (OR) with 95% confidence intervals (95%CI). Heterogeneity was assessed using Q and I[2] statistic.

      Result:
      Finally, three studies with a total of 288 patients from Asian countries were identified as eligible publications. The presence of EGFR mutation was significantly related to HPV DNA compared with HPV negative controls (57% vs. 27%，OR 3.91, 95% CI 1.85 to 5.50; p<0.001), with no statistical heterogeneity among studies (I[2]=0; p=0.525).

      Conclusion:
      Our results suggest that HPV may contribute in part to EGFR mutations in non-small cell lung cancer, at least in Asian population.

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