Author of

• 20155

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  P1.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 692)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22649

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    P1.06-005 - Sex-Based Disparities in NSCLC: An Evidence-Based Study  (ID 8499)

    09:30 - 09:30  |  Author(s): M. Hollenberg
    • Abstract

    Background:
    Previous studies report intrinsic sex differences among lung cancer patients; however, current epidemiological data remains inconclusive as to the existence and impact of inherent sex differences. This study aimed to perform a descriptive evidence-based study of the literature to identify and quantify sex-associated characteristics among non-small lung cancer (NSCLC) patients.
    
    Method:
    We retrieved all potentially relevant articles published in English by searching Medline between 1996 and 2016, worldwide. Using a systematic review protocol, all abstracts were reviewed for eligibility, and studies meeting inclusion criteria retained. We identified eligible studies on NSCLC and its subtypes, with the inclusion of both men and women of age over 45 in the study population. Pooled data was analyzed using a semi-parametric longitudinal regression model and an ANOVA Two-way test. A data-visualization tool was used to demonstrate global NSCLC incidence distribution and sex-based disparities.
    
    Result:
    Of 1405 articles identified on Medline, 46 studies met eligibility requirements; 36 were included in statistical analyses, and 10 underwent descriptive-systematic review. We found that disparities between the sexes are significant (p=0.01). Among men, we found a significant effect of race on age-standardized incidence rates (ASR) in this subset (p <0.001). Among women, the incidence of NSCLC was found to increase over time, irrespective of race. For adenocarcinoma (ADC), a significant interaction between sex and race was found (p=0.02), with women showing higher rates of ADC than men. Asians, however, had the highest rates of ADC among other races. For squamous cell histology (SCC), no interaction between sex and race was found (p=0.7); however, a significant difference in SCC incidence rates was found between the sexes (p= 0.01). Analyzing SCC data shows significant effect over time by gender (p=0.02), with ASR values in males decreasing by -0.31 units per year. Conversely, the data-visualizing tool showed an increase in incidence rates of SCC among Canadian women.
    
    Conclusion:
    Our findings demonstrate that NSCLC trends vary by sex, and both race and sex have a significant affect on incidence rates. However, the inclusion of women in clinical studies is increasing over time, and women often express ADC. This histology is also predominant among all Asians. Findings also illustrated that global trends do not always align with regional trends. Our study serve as a basis to begin to resolve the inherent controversies in the research, and highlight the importance of the inclusion of sex as a risk modifier in the development of screening initiatives and therapies in NSCLC.