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L. Vera
Author of
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P1.05 - Early Stage NSCLC (ID 691)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Early Stage NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.05-022 - Association Between Neutrophil/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio with Disease Free Survival in Operated NSCLC Patients in Peru (ID 10372)
09:30 - 09:30 | Author(s): L. Vera
- Abstract
Background:
Tumor recurrence after surgical resection is the main obstacle for long term survival in patients with NSCLC. The identification of factors related to recurrence may help to determine new risk predictors and guide different forms of treatment. An elevated neutrophil to lymphocyte ratio (NLR) and a low lymphocyte to monocyte ratio (MNR) have been reported to be poor predictors of disease free survival (DFS) in patients with NSCLC. There is a lack of evidence on the association of these ratios in early stages of lung cancer.
Method:
Data of NSCLC patients who were lobectomized at Edgardo Rebagliati Hospital between years 2008-2014 were retrospectively reviewed. Patients with incomplete data were excluded. NLR and LMR were calculated before surgery. DFS was determinate according to Kaplan-Meier method, the comparison of the survival curves was made by Logrank test or Cox model.
Result:
Forty patients were included. The median age was 68.5 years old, 52.5% were men and 92% had an ECOG scale 1. The 32.5% were asymptomatic at the time of diagnosis and 22.5% were in pre-surgical evaluation for different diseases. The 57.5%, 32.5% and 10% of patients had clinical stage I, II and IIIA, respectively. The 80% of patients had adenocarcinoma and the 20% had a squamous subtype. The 36.1% and 63.9% of the patients had NLR < 1.5 and >1.5, meanwhile 8.6% and 91.4% of the patients had LMR < 2.3 and >2.3, respectively. The median follow-up was 4.4 years, in which the 40% of patients died. The DFS rate at 4-years was 40.5%. Three patients had LMR < 2.3, all of them have died during follow up. The variables associated to DFS were lymphatic permeation (HR: 3.2, p=0.011), tumor size > 5 cm (HR: 1.2, p=0.028) and NLR (HR: 3.5, p=0.136). DFS rate at 4-years was 75% in patients with NLR < 1.5 and 28.5% in those with NLR >1.5.
Conclusion:
A NLR > 1.5 before surgery is associated with a worse DFS than patients who had a NLR < 1.5. Studies with a bigger number of patients are needed to determine the importance of NLR and LMR as recurrence predictors in operated patients with NSCLC. This result encourages further investigation about available and inexpensive biomarkers as predictors of disease recurrence in early stages of lung cancer.
