Author of

• 20154

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  P1.05 - Early Stage NSCLC (ID 691)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22628

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    P1.05-006 - Clinicopathological Features of Small-Sized Peripheral Squamous Cell Lung Cancer (ID 9203)

    09:30 - 09:30  |  Author(s): K. Obayashi
    • Abstract

    Background:
    Recent advances in imaging technology have enhanced the detection rate of small-sized peripheral lung cancers. While squamous cell carcinoma (SCC) had previously been regarded as a representative histological type of centrally-located lung cancer, recent studies have reported an increase in peripheral SCC. In order to reveal the malignancy of such peripheral lung cancer, we retrospectively compared the clinicopathological features of small-sized peripheral SCC with that of adenocarcinoma (ADC) in surgically resected cases.
    
    Method:
    We retrospectively analyzed lung cancer patients who underwent radical surgical resections at Gunma University Hospital between July 2007 and October 2011. We included all 26 patients diagnosed with SCC and 214 patients diagnosed with ADC who had tumors smaller than 2 cm in pathological size.
    
    Result:
    Patients with SCC were significantly older than those with ADC. In SCC patients, 80% of patients were male and almost all patients were smoker, whereas in ADC patients, only half of patients were male and smoker. For pathological stage, only 62% of SCC were staged IA whereas 85% of ADC were staged IA. On the other hand, 16% of SCC were staged IIA to IIIA whereas only 8% of ADC were staged IIA to IIIA. SCC patients tended to have higher rate of lymph node metastasis compared to ADC patients, although there was no significant difference (16% vs. 8%; p = 0.25). The incidences of pleural invasion (31% vs. 12%; p < 0.01), vascular invasion (50% vs. 19%; p < 0.01), and lymphatic invasion (50% vs. 15%; p < 0.01) were significantly higher in SCC than in ADC. Rate of postoperative recurrence was higher in SCC patients compared to ADC patients (23% vs. 10%; p = 0.04), although there was no significant difference in pattern of recurrence. Five-year survival rate of SCC was significantly shorter compared to that of ADC (60% vs. 94%; p < 0.01).
    
    Conclusion:
    SCC patients had worse prognosis compared to ADC patients, although there was no difference in lymph node metastasis. Adjuvant chemotherapy should be considered in SCC patients in order to improve treatment outcome.