Author of

• 20152

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  P1.03 - Chemotherapy/Targeted Therapy (ID 689)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Chemotherapy/Targeted Therapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22601

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    P1.03-046 - A Retrospective Analysis of Correlation Between Cytokines in TME and Therapeutic Effect of Advanced Lung Cancer Chemotherapy in China (ID 10502)

    09:30 - 09:30  |  Author(s): A. Xiong
    • Abstract

    Background:
    Chemotherapy plays an important role in the treatment of lung cancer in the world as well as in China. Studies showed that chemotherapeutic drugs may change the interactions of cancer cells and TME. A number of international studies have changed the treatment paradigm of advanced lung cancer. Since we already entered into a new era of immunotherapy, positive reactions of immunotherapy usually related to the changes of TME. This retrospective study was designed to evaluate relationship between immune-related cytokines in TME and chemotherapy in advanced lung cancer.
    
    Method:
    A total of 728 patients with advanced lung carcinoma diagnosed and treated in Shanghai pulmonary hospital from June 2010 to June 2015 were included. IL-1, IL-2R, IL-5, IL-6, IFN-γ,TNF and different cut off values of the 6 cytokines (25%, 50%, 75%, 90%, median level) as well as proportion and ratio of CD4+T lymphocytes and CD8+T lymphocytes were analyzed by Flow Cytometry before and after chemotherapy.
    
    Result:
    Median age at diagnosis was 61 (19-83 years), and median OS was 435 days. Our results suggested that IFN-γ(cut off value 25%) had significant correlation with OS after first-line chemotherapy (OS:below25% vs above25% 406 vs 463 days, log-rank p=0.049). Other factors ,such as IL-1, IL-2R, IL-5, IL-6, TNF, did not showed statistically significant with the chemotherapy and PFS or OS (log-rank p>0.05 for all).
    
    Conclusion:
    IFN-γ is a predictive and prognostic factor of advanced NSCLC independent of chemotherapy. The results of our study may be expected to serve as useful information of influence by chemotherapy on TME and may indicate treatment sequence in the near future.