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K. Takagi
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P1.03 - Chemotherapy/Targeted Therapy (ID 689)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Chemotherapy/Targeted Therapy
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.03-031 - Adherence and Feasibility of 2 Treatment Schedules of S-1 as Adjuvant Chemotherapy in Completely Resected Lung Cancer (ID 8829)
09:30 - 09:30 | Author(s): K. Takagi
- Abstract
Background:
S-1 is one of the key-drugs as chemotherapy for the non-small cell lung cancer (NSCLC). We conducted a multicenter randomized study of adjuvant S-1 administration schedules for surgically treated pathological stage IB-IIIA NSCLC patients.
Method:
Patients receiving curative surgical resection were centrally randomized to arm A (4 weeks of oral S-1 and a 2-week rest over 12 months) or arm B (2 weeks of S-1 and a 1-week rest over 12 months). The primary endpoints were total days of administration, and the secondary endpoints were relative total administration dose (relative dose intensity), toxicity, and 3-year disease-free survival. Total days of administration were evaluated according to the cumulative rates of total S-1 administration days within 224 days, at the end of 12 months. Relative dose intensity was defined as (the actual total dose administered divided by the planned total administered dose) × 100.
Result:
From April 2005 to January 2012, 80 patients were enrolled, of whom 78 patients were eligible and assessable. The cumulative rates of total S-1 administration days at the end of 12 months, were 81.3% for arm A (38 cases) and 60.2% for arm B patients (40 cases, p = 0.04). The relative dose intensity was 77.2% for arm A and 58.4% for arm B (p = 0.01). Drug-related grade 3 adverse events were recorded for 11% of arm A and 5% of arm B (p = 0.43). The 3-year disease-free survival rate was 79.0% for arm A and 79.3% for arm B (p = 0.94). Toxicity showed no significant difference among the shorter schedule and the conventional schedule, except for grade 1-3 elevation of bilirubin.
Conclusion:
The superiority of feasibility of the shorter schedule was not recognized in the present study. The conventional schedule showed higher cumulative rates of total S-1 administration days at the end of 12 months (p = 0.04) and relative dose intensity of S-1 (p = 0.01).
