Author of

• 20152

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  P1.03 - Chemotherapy/Targeted Therapy (ID 689)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Chemotherapy/Targeted Therapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 22562

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    P1.03-007 - A Real-World Study of Clinicopathological Characteristics and Survival Outcome in Advanced ALK-Positive Non-Small-Cell Lung Cancer (ID 8775)

    09:30 - 09:30  |  Author(s): Y. Chen
    • Abstract

    Background:
    Crizotinib has resulted in substantial benefits for advanced non-small- cell lung cancer (NSCLC) patients harboring anaplastic lymphoma kinase (ALK) rearrangement. With limited real-world data available, the present work aimed to explore the clinicopathological characteristics and survival outcome of patients with advanced ALK+ NSCLC in a single center in China.
    
    Method:
    Data of 83 advanced ALK-rearranged NSCLC patients treated in Zhejiang Cancer Hospital were collected and analyzed retrospectively. Survivals were analyzed using the Kaplan-Meier method and were compared using the log-rank test. Multivariate analysis were performed by the Cox proportional hazard model.
    
    Result:
    Of the 83 patients enrolled, 33(39.8%) patients received crizotinib, and the other 50(60.2%) patients received chemotherapy as the initial treatment. The first-line use of crizotinib prolonged PFS compared with chemotherapy (median PFS 19.0 m vs. 5.7 m, P < 0.001), but not OS (46.0 m vs. 30.6 m, P=0.797). Till the last follow up, 71(85.5%) patients had received crizotinib, and 12(14.5%) patients were crizotinib-naïve. Patients who had received crizotinib had significantly longer OS than those who did not (48.9 m vs. 19.8 m, P < 0.05). Among the 71 patients who had received crizotinib,33(46.5%) used in first-line therapy, 22(31.0%) used in second-line therapy, and 16(22.5%) used after second-line therapy. There were not significant difference of OS among the three groups (30.6 m vs. 57.7 m vs. 40.8 m, P=0.583). The Cox multivariate analysis identified the following independent negative prognostic factors for OS: smoking (HR=4.725), liver metastasis(HR=4.570), bone metastasis (HR=2.651), and use of crizotinib (HR=0.295).
    
    Conclusion:
    Our real-world study showed that the use of crizotinib improved long-term survival of patients with advanced ALK-rearrangement NSCLC. There were no difference in survival outcome between patients with initial crizotinib and those with non-initial crizotinib.