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S. Lee
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P1.02 - Biology/Pathology (ID 614)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.02-024 - Correlation of Maximal Tumor Diameter between Pathology Specimen and CT in Nonsmall Cell Lung Cancer: A Pilot Study (ID 8201)
09:30 - 09:30 | Author(s): S. Lee
- Abstract
Background:
Tumor size has been recognized as an important prognostic factor. In renal tumor, CT imaging generally overestimates pathological tumor size. However, systematic correlation of tumor size between pathology and radiology in lung cancer has not been studied yet. Herein, we compared the maximal tumor diameter between surgically resected fresh lung tissue and chest CT.
Method:
Our study included 75 surgically resected nonsmall cell lung cancer specimens submitted in a fresh state. Pathologic tumor size (PTS) was obtained by measuring the largest cross-sectional tumor diameters in the fresh specimen. Radiologic tumor size (RTS) was retrospectively measured in axial (RTSax) and reconstructed oblique (RTSrecon) image of chest CT. Tumors larger than 4 cm, tumors with uncertain margins owing to underlying lung fibrosis or pneumonia, and tumors sectioned in formalin-fixed state were excluded.
Result:
The mean PTS, RTSax, and RTSrecon with standard deviation were 2.1cm ± 0.815, 2.068cm ± 0.822, and 2.26cm ± 0.871, respectively. PTS and RTrecon was significantly different (PTS-RTSrecon: -1.179±0.404, p<0.001), while there was no statistically significant difference between PTS and RTSax. Scatter plot and linear regression analysis demonstrated a strong positive correlation between PTS and RTS (PTS = 0.395+0.824xRTSax, p<0.001; PTS=0.233+0.818xRTSrecon, p<0.001). The intraclass correlation coefficient (ICC) between PTS and RTSax was 0.832 (95% confidence interval, 0.747-0.890). The ICC between PTS and RTSrecon was 0.884 (95% confidence interval, 0.822-0.925). There was no significant difference between PTS and RTS associated with histologic subtype, specimen type, warm ischemic time, predominant lepidic histology, pleura invasion, and gross feature.
Conclusion:
Both RTSax and RTSrecon were significantly correlated with PTS. Reliability analysis showed that RTSrecon correlated with PTS slightly better than RTSax, although RTSrecom tended to overestimate PTS. Further study with larger sample size would be needed.
