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M. Zhang
Author of
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P1.01 - Advanced NSCLC (ID 757)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.01-072 - Epithelial-To-Mesenchymal Transition (EMT) in Lung Cancer: Classic Reproduction (ID 8195)
09:30 - 09:30 | Author(s): M. Zhang
- Abstract
Background:
Lung cancer is the one of the highest incidence and fatality disease in the world wide. Although several of treatments have been found such as chemotherapy, radiotherapy and target therapy, lung cancer treatments remain many obstacles, for instance, drug resistant and gene mutant.
Method:
Epithelial-to-mesenchymal transition (EMT) process is a traditional pathway in cells program, during this process cells loss epithelial marker and acquire mesenchymal characteristic. EMT associates with cancer cell migration and invasion, more EMT process predicts poor prognosis and the resistant to chemotherapy even target treatment. More therapy target to EMT process such as some markers or signaling pathway. In this review, we discussed the new relationship of EMT and lung cancer. Some compounds which inhibited cancer cells acted with regulator of EMT or EMT process. Recent years, the target treatment and even the immune therapy were appeared in National Comprehensive Cancer Network guideline.
Result:
The effective treatment of lung cancer is correlated with EMT process. In vivo and in vitro research showed that occurrence of EMT process predicted poor prognosis and treatment failure in target and immune therapy.
Conclusion:
With the development of lung cancer treatment, EMT process may become a key research target.
