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R. D'Avila
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P1.01 - Advanced NSCLC (ID 757)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.01-063 - Are the Real World Patients with Advanced Non-Small Cell Lung Cancer Represented in Phase III Immunotherapy Trials? (ID 9801)
09:30 - 09:30 | Author(s): R. D'Avila
- Abstract
Background:
Several randomized phase III trials with immune checkpoints inhibitors have accrued patients with metastatic non-small cell lung cancer (NSCLC). These trials employed strict patient selection criteria, and it is currently unknown how it represents the ‘real-world’ population.
Method:
From January 2011 to December 2016, all patients with metastatic NSCLC referred for first oncological evaluation at two University Hospitals in South of Brazil were identified by electronic database and included in the analysis. Twelve pre-defined eligibility criteria, all used in the recent first line phase III immunotherapy trial, were analyzed. OS and PFS were estimated by Kaplan-Meier curves. Multivariate analysis was performed to identify factors associated with survival. Statistical analysis was performed with SPSS 22.0.
Result:
Three hundred and nine patients were collected for this analysis. Patient characteristics revealed a mean age of 63.73 ± 09.47 years, 56% male and 65% had adenocarcinoma. One hundred ninety-seven (64%) patients did not meet one or more eligible criteria at first evaluation. ECOG performance status ≥2 (118 patients) and active brain metastasis (69 patients) accounted alone for 79.7% of non-eligibility cases. One hundred (50.76%), 53 (26.9%), 30 (15.22%) and 14 (7.1%) had 1, 2, 3 or 4 non-eligible criteria respectively. The median survival after the diagnosis of metastatic disease was 6.34 (95% IC, 5.59 to 7.08) months in the non-eligible group and 11.07 (95% IC, 8.65 to 13.48; p<0.001) in the eligible group. The hazard ratio of 1.90 (95% IC, 1.46 to 2.47) to mortality in the non-eligible group should reflect the worse baseline prognostic features in this group.
Conclusion:
To our knowledge, this is the first report of metastatic NSCLC patients analyzed regarding the eligible criteria of the phase III trials. It is clear that clinical trials do not represent the “real world” population and its outcomes have an important selection bias. Phase III clinical trials eligibility criteria should be reviewed to better represent the NSCLC population.
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P3.16 - Surgery (ID 732)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.16-034 - Impact of Travel Distance to Treatment Institution on Survival from Stage I to III Lung Cancer (ID 10350)
09:30 - 09:30 | Author(s): R. D'Avila
- Abstract
Background:
Over the last decade, attention and emphasis on regionalization of care for tertiary hospitals have increased in order to improve outcomes, especially in complex surgical procedures such as resection of lung cancer. On the other hand, the growing centralization of cancer services increases patient displacement and may delay access to specialized services and treatment. Impact of travel distance on patients’ outcome from lung cancer is poorly described. The objective of this study is to evaluate whether distance to treatment institution has an impact on survival from patients with lung cancer.
Method:
This is an observational, retrospective study, which included patients with stage I-III lung cancer that performed curative resection at Hospital São Lucas da PUCRS, Brazil. Data was collected from medical charts including demographic, clinical-pathological features and survival. Survival was estimated using the Kaplan-Meier method and log-rank test was used to perform multivariate analysis for prognostic factors. Chi-squared test was used to compare variables between groups.
Result:
Between January 2011 and December 2015, 234 patients with stage I-III lung cancer performed curative resection at Hospital São Lucas da PUCRS. The median age was 65 years (24-85 years) and 50.85% were male. 147 (62.82%) patients were from public health insurance and 87 (37.18%) had private coverage. The distribution of clinical stage ( AJCC 8th ed) was : 116 (49.57%) stage I, 71 (30.34%) stage II and 47 (20.09%) stage III. The median distance to institution was 19.7 (2-1086 km). Patients with public health insurance traveled higher distance than those with private coverage (p= 0.0004). The 3-year overall survival was 86.13% for stage I, 77.74% for stage II and 48.95% for stage III. The distance to institution had no impact in overall survival (p=0.85 for stage I, p= 0.63 for stage II and p= 0.46 for stage III).
Conclusion:
Our study shows that the distance between residence and treatment institution was not found to influence survival of the patients with lung cancer treated by surgery. Importantly, patients with public health insurance, which are in general poorer, have to travel longer distances for curative treatment.
