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Yutaka Oshima



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    P3.16 - Surgery (ID 732)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Surgery
    • Presentations: 1
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      P3.16-008 - Thymidine Phosphorylase Influences Clinical Outcome Following Surgery in Patients with Stage I and II Non-Small Cell Lung Cancer (ID 9665)

      09:30 - 09:30  |  Author(s): Yutaka Oshima

      • Abstract

      Background:
      Expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), and orotate phosphoribosyltransferase (OPRT) may predict the clinical efficacy of 5-fluorouracil (5-FU) -based chemotherapy in patients with cancer. We investigated the differences in mRNA expression levels of these enzymes in non-small-cell lung cancer (NSCLC) and evaluated them as prognostic factors for NSCLC treated by surgical resection.

      Method:
      Intratumoral mRNA levels of TS, DPD, OPRT, and TP were quantified in 71 patients following a complete resection in pathological stage I and II NSCLC (adenocarcinoma or squamous cell carcinoma) using the Danenberg tumor profile (DTP) method.

      Result:
      TP was the only significant prognostic factor for overall survival (OS) following complete resection of stage I and II NSCLC. Median values of TP mRNA expression significantly differed between the high and low mRNA expression groups for OS. OS at 5 years was significantly better in the low TP mRNA expression group than the high TP mRNA expression group (82.5% vs. 63.6%, p < 0.001). The Cox’s proportional hazard model indicated that the pathological stage, sex, and TP expression were independent prognostic factors for OS. Univariate analysis for disease free survival (DFS) indicated that the pathological stage was the only prognostic factor for DFS. However, DFS at 5 years tended to be better in low TP mRNA expression group than in high TP mRNA expression group (88.9% vs. 67.3%, p=0.083).

      Conclusion:
      TP mRNA expression presents an independent prognostic factor for OS in patients with stage I and II NSCLC following complete resection.