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Minhua Shi
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P2.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 707)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.06-010 - Association of Vitamin D Receptor BsmI Polymorphism with Lung Cancer Risk: Evidence from a Meta-Analysis (ID 10432)
09:30 - 09:30 | Presenting Author(s): Minhua Shi
- Abstract
Background:
Several studies have reported an association between the BsmI polymorphism of vitamin D receptor(VDR) and lung ancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between the BsmI polymorphism of VDR and susceptibility to lung cancer.
Method:
Published case-control and cohort-based studies from PubMed ,Embase, Wanfang, and CNKI were retrieved, and data were manually extracted. The odds ratios (ORs) and 95% confidence intervals (CIs) of the included studies were pooled. Begg’s and Egger’s test were used to evaluate publication bias.
Result:
Nine articles with 2343 cases and 1578 controls were included. The pooled effect size showed an association between the BsmI polymorphism and the risk of lung cancer (dominant model, OR: 0.58, 95% CI: 0.41–0.82; allele model, OR: 0.67, 95% CI: 0.52–0.86). In a subgroup analysis, a significant association between the BsmI polymorphism and low lung cancer susceptibility was detected among Asians (dominant model, OR: 0.47, 95% CI: 0.35–0.62; allele model, OR: 0.54, 95% CI: 0.41–0.71).
Conclusion:
The BsmI polymorphism was found to be significantly associated with a decreased risk of lung cancer, particularly in Asians.
